INTERROGATING THE GENOME TO UNCOVER HUMAN SPECIALIZATIONS OF BRAIN & COGNITION

探究基因组以揭示人类大脑的特化

• 批准号: 8357405
• 负责人: TODD M PRUESS
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357405
• 关键词: Activities of Daily Living; Brain; Brain region; Cognition; Elements; Funding; Gene Expression; Genome; Golgi Apparatus; Grant; Human; Label; Macaca; Monkeys; Morphology; National Center for Research Resources; Pan Genus; Primates; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Site; Source; Synapses; United States National Institutes of Health; Vertebral column; Work; base; cost; frontal lobe; nonhuman primate; postsynaptic; presynaptic; protein expression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Human brains have unique functional capacities, but how the human brain differs structurally and biochemically from that of other primates is poorly understood. We are pursuing these questions by identifying differences in gene and protein expression between species (humans, chimpanzees, and macaque monkeys), between brain regions (multiple cortical and subcortical sites), and between hemispheres. During 2010, we have worked on obtaining Golgi sections for comparing synaptic spine numbers and morphology in frontal cortex of humans, chimpanzees, and macaques, based on observed differences in gene expression. We have also obtained confocal photomicrographs comparing labeling of pre- and postsynaptic elements for synaptic proteins that are differentially expressed in the frontal cortex of humans and nonhuman primates.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 人的大脑具有独特的功能能力，但是人脑在结构和生物化学上与其他灵长类动物的差异差异很差。 我们正在通过鉴定物种（人类，黑猩猩和猕猴），大脑区域（多层皮质和皮层下部位）以及半球之间的物种（人类，黑猩猩和猕猴）之间的基因和蛋白质表达的差异来追求这些问题。 在2010年期间，根据观察到的基因表达的差异，我们一直致力于获得高尔基体切片，以比较人类，黑猩猩和猕猴的突触脊柱数量和形态。 我们还获得了共聚焦显微照片，比较了突触前和突触后元素的突触蛋白的标记，这些突触蛋白在人类和非人类灵长类动物的额叶皮层中差异表达。