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Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System

约翰尼·比·古德：以蜜蜂为模型来研究奖励系统的劫持

基本信息

批准号：
8142168
负责人：
GENE E ROBINSON
金额：
$ 78.46万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-07-31
项目状态：
已结题

项目摘要

Abstract The circuits in the brain that mediate our perception of reward, known collectively as the "reward system," couple pleasure with the essentials of life: food and reproduction. The reward system also lies at the root of some of the most tragic, harmful, and costly behaviors in our society. These include addiction to substances of abuse, obesity-related behavior, dangerous thrill seeking behavior, and aberrant sexual behavior. Research that I performed on altruistic behavior in honey bees has led me to a new insight about the reward system. Finding that the same neurochemical system that modulates selfish behavior in solitary insects modulates altruistic behavior in the highly social honey bee, I conclude that not only is the reward system vulnerable to "hijacking"- -coupling to stimuli with negative consequences-- over the course of a lifetime as mentioned above, but it also is vulnerable to hijacking in evolutionary time. I propose to use 'omic technologies (high-throughput sequencing, transcriptomics, epigenomics, proteomics, and metabolomics) to understand in molecular terms how to "flip" the reward system, from selfish to altruistic behavior. These analyses will be performed on a carefully selected set of closely related species of bees, some social (with altruistic behavior) and some solitary (without). The insights gained from this novel synthesis of systems biology, neuroscience, and evolutionary biology will transform our understanding of drug addiction and other diseases of the reward system and provide the foundation for new forms of therapeutic intervention.

抽象的大脑中调节我们对奖励感知的回路，统称为“奖励系统”，将快乐与生活必需品：食物和繁殖结合起来。奖励制度也是我们社会中一些最悲惨、最有害、代价最高的行为的根源。这些包括对滥用物质的成瘾、与肥胖相关的行为、危险的寻求刺激的行为和异常的性行为。我对蜜蜂的利他行为进行的研究使我对奖励系统有了新的认识。我发现调节独居昆虫的自私行为的神经化学系统也调节高度社会化蜜蜂的利他行为，我得出的结论是，如上所述，奖励系统不仅在一生中容易受到“劫持”（与具有负面后果的刺激相结合）的影响，而且在进化过程中也容易受到劫持。我建议使用“组学”技术（高通量测序、转录组学、表观基因组学、蛋白质组学和代谢组学）来从分子角度理解如何“翻转”奖励系统，从自私行为转变为利他行为。这些分析将针对一组精心挑选的密切相关的蜜蜂物种进行，其中一些是群居的（具有利他行为），一些是独居的（没有利他行为）。从系统生物学、神经科学和进化生物学的新颖综合中获得的见解将改变我们对药物成瘾和奖赏系统其他疾病的理解，并为新形式的治疗干预奠定基础。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transcriptomic analysis of instinctive and learned reward-related behaviors in honey bees.

蜜蜂本能和习得的奖励相关行为的转录组分析。

DOI：
10.1242/jeb.144311
发表时间：
2016
期刊：
The Journal of experimental biology
影响因子：
0
作者：
Naeger,NicholasL;Robinson,GeneE
通讯作者：
Robinson,GeneE

Caste-specific differences in hindgut microbial communities of honey bees (Apis mellifera).

DOI：
10.1371/journal.pone.0123911
发表时间：
2015
期刊：
PloS one
影响因子：
3.7
作者：
Kapheim KM;Rao VD;Yeoman CJ;Wilson BA;White BA;Goldenfeld N;Robinson GE
通讯作者：
Robinson GE

Social evolution. Genomic signatures of evolutionary transitions from solitary to group living.

DOI：
10.1126/science.aaa4788
发表时间：
2015-06-05
期刊：
Science (New York, N.Y.)
影响因子：
0
作者：
Kapheim KM;Pan H;Li C;Salzberg SL;Puiu D;Magoc T;Robertson HM;Hudson ME;Venkat A;Fischman BJ;Hernandez A;Yandell M;Ence D;Holt C;Yocum GD;Kemp WP;Bosch J;Waterhouse RM;Zdobnov EM;Stolle E;Kraus FB;Helbing S;Moritz RF;Glastad KM;Hunt BG;Goodisman MA;Hauser F;Grimmelikhuijzen CJ;Pinheiro DG;Nunes FM;Soares MP;Tanaka ÉD;Simões ZL;Hartfelder K;Evans JD;Barribeau SM;Johnson RM;Massey JH;Southey BR;Hasselmann M;Hamacher D;Biewer M;Kent CF;Zayed A;Blatti C 3rd;Sinha S;Johnston JS;Hanrahan SJ;Kocher SD;Wang J;Robinson GE;Zhang G
通讯作者：
Zhang G

Conservation in Mammals of Genes Associated with Aggression-Related Behavioral Phenotypes in Honey Bees.

哺乳动物中与蜜蜂攻击相关行为表型相关的基因的保护。