Johnny Bee Good: Bees as Models to Study the Hijacking of the Reward System

约翰尼·比·古德：以蜜蜂为模型来研究奖励系统的劫持

• 批准号: 7844370
• 负责人: GENE E ROBINSON
• 金额: $ 79.25万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844370
• 关键词: Address; Bees; Behavior; Biology; Brain; Budgets; Coupling; Dangerous Behavior; Disease; Drug Addiction; Food; Foundations; Honey; Insecta; Life; Mediating; Modeling; Molecular; Neurosciences; Obesity; Outcome; Perception; Plant Roots; Proteomics; Public Health; Recommendation; Reproduction; Research; Review Committee; Rewards; Sex Behavior; Societies; Stimulus; Substance of Abuse; System; Systems Biology; Therapeutic Intervention; Time; abstracting; addiction; base; epigenomics; high throughput technology; insight; metabolomics; neurochemistry; novel; pleasure; public health relevance; social; transcriptomics

DESCRIPTION Abstract The circuits in the brain that mediate our perception of reward, known collectively as the "reward system," couple pleasure with the essentials of life: food and reproduction. The reward system also lies at the root of some of the most tragic, harmful, and costly behaviors in our society. These include addiction to substances of abuse, obesity-related behavior, dangerous thrill seeking behavior, and aberrant sexual behavior. Research that I performed on altruistic behavior in honey bees has led me to a new insight about the reward system. Finding that the same neurochemical system that modulates selfish behavior in solitary insects modulates altruistic behavior in the highly social honey bee, I conclude that not only is the reward system vulnerable to "hijacking"- -coupling to stimuli with negative consequences-- over the course of a lifetime as mentioned above, but it also is vulnerable to hijacking in evolutionary time. I propose to use 'omic technologies (high-throughput sequencing, transcriptomics, epigenomics, proteomics, and metabolomics) to understand in molecular terms how to "flip" the reward system, from selfish to altruistic behavior. These analyses will be performed on a carefully selected set of closely related species of bees, some social (with altruistic behavior) and some solitary (without). The insights gained from this novel synthesis of systems biology, neuroscience, and evolutionary biology will transform our understanding of drug addiction and other diseases of the reward system and provide the foundation for new forms of therapeutic intervention. Public Health Relevance This project addresses the molecular basis of drug addiction and other diseases of the reward system, which are serious public health concerns. THE FOLLOWING RESUME SECTIONS WERE PREPARED BY THE SCIENTIFIC REVIEW OFFICER TO SUMMARIZE THE OUTCOME OF DISCUSSIONS OF THE REVIEW COMMITTEE ON THE FOLLOWING ISSUES. COMMITTEE BUDGET RECOMMENDATIONS: The budget was recomme

描述 抽象的 大脑中调节我们对奖励感知的回路，统称为“奖励系统”，将快乐与生活必需品：食物和繁殖结合起来。奖励制度也是我们社会中一些最悲惨、最有害、代价最高的行为的根源。这些包括对滥用物质的成瘾、与肥胖相关的行为、危险的寻求刺激的行为和异常的性行为。我对蜜蜂的利他行为进行的研究使我对奖励系统有了新的认识。我发现调节独居昆虫的自私行为的神经化学系统也调节高度社会化蜜蜂的利他行为，我得出的结论是，如上所述，奖励系统不仅在一生中容易受到“劫持”（与具有负面后果的刺激相结合）的影响，而且在进化过程中也容易受到劫持。我建议使用“组学”技术（高通量测序、转录组学、表观基因组学、蛋白质组学和代谢组学）来从分子角度理解如何“翻转”奖励系统，从自私行为转变为利他行为。这些分析将针对一组精心挑选的密切相关的蜜蜂物种进行，其中一些是群居的（具有利他行为），一些是独居的（没有利他行为）。从系统生物学、神经科学和进化生物学的新颖综合中获得的见解将改变我们对药物成瘾和奖赏系统其他疾病的理解，并为新形式的治疗干预奠定基础。 公共卫生相关性 该项目解决了毒瘾和奖励系统其他疾病的分子基础，这些疾病是严重的公共卫生问题。 以下简历部分由科学审查官员准备，以总结审查委员会关于以下问题的讨论结果。 委员会预算建议： 预算被推荐