T1RHO MRI OF THE HUMAN BRAIN USING A SPIN-LOCKED SSFP PULSE SEQUENCE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this work, we describe a new pulse sequence (SL-TRUFI) based on a balanced steady-state free precession or true-FISP (TRUFI) pulse sequence. MR imaging was performed on 2 normal volunteers (mean age: 25¿4) on a Siemens 3 Tesla Trio clinical scanner with the vendor-supplied head coil. The pulse sequence is faster than the single slice method for T1? mapping.