MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

通过小角 X 射线散射研究 T=4 病毒衣壳的成熟动力学

• 批准号: 8170321
• 负责人: John Emil Johnson
• 金额: $ 0.34万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170321
• 关键词: Capsid; Capsid Proteins; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Proteolysis; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Virus; Virus-like particle; member; receptor binding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 病毒的成熟通常是通过对低pH，DNA/RNA包装和受体结合等环境信号的响应引起的。在许多情况下，它们伴随着衣壳蛋白的急剧构象变化。 Nudaurelia capensis欧米茄病毒（NV）是四病毒的成员，t = 4个非发育的二十面体ssRNA病毒。通过降低pH值诱导的pH依赖性大构象变化（LCC），NV外套蛋白的病毒（VLP）类似于NV外套蛋白（VLP）（VLP）（VLP）（VLP）（VLP）