MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 病毒的成熟通常是由对低pH、DNA/RNA包装和受体结合等环境信号的反应诱导的。在许多情况下，伴随着衣壳蛋白的戏剧性构象变化。卡氏新月形体omega病毒(NV)是TetraVirus的成员，T=4个无包膜的二十面体单链RNA病毒。NV外壳蛋白的病毒样颗粒(VLP)在降低pH(

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (