MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

通过小角 X 射线散射研究 T=4 病毒衣壳的成熟动力学

• 批准号: 8170321
• 负责人: John Emil Johnson
• 金额: $ 0.34万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170321
• 关键词: Capsid; Capsid Proteins; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Proteolysis; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; Virus; Virus-like particle; member; receptor binding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 病毒成熟通常是由对环境信号的反应诱导的，如低pH、DNA/RNA包装和受体结合。在许多情况下，它们伴随着衣壳蛋白的急剧构象变化。角裸尾虫欧米伽病毒（NV）是四病毒属的成员，T=4无包膜二十面体ssRNA病毒。NV外壳蛋白的病毒样颗粒（VLP）在pH依赖性的大构象变化（LCC）后发生自蛋白水解，