MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

通过小角 X 射线散射研究 T=4 病毒衣壳的成熟动力学

• 批准号: 8362317
• 负责人: John Emil Johnson
• 金额: $ 1.04万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362317
• 关键词: Capsid; Capsid Proteins; DNA; Funding; Grant; National Center for Research Resources; Principal Investigator; Proteolysis; RNA; Radiation; Research; Research Infrastructure; Resources; Roentgen Rays; Signal Transduction; Source; United States National Institutes of Health; Virus; Virus-like particle; cost; member; receptor binding; response; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 病毒成熟通常是由对环境信号的反应诱导的，如低pH、DNA/RNA包装和受体结合。在许多情况下，它们伴随着衣壳蛋白的急剧构象变化。角裸尾虫欧米伽病毒（NV）是四病毒属的成员，T=4无包膜二十面体ssRNA病毒。NV外壳蛋白的病毒样颗粒（VLP）在pH依赖性的大构象变化（LCC）后发生自蛋白水解，