MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 病毒的成熟通常是由对低pH、DNA/RNA包装和受体结合等环境信号的反应诱导的。在许多情况下，伴随着衣壳蛋白的戏剧性构象变化。卡氏新月形体omega病毒(NV)是TetraVirus的成员，T=4个无包膜的二十面体单链RNA病毒。NV外壳蛋白的病毒样颗粒(VLP)在降低pH(

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (