MATURATION DYNAMICS OF T=4 VIRUS CAPSID BY SMALL-ANGLE X-RAY SCATTERING

通过小角 X 射线散射研究 T=4 病毒衣壳的成熟动力学

• 批准号: 8362317
• 负责人: John Emil Johnson
• 金额: $ 1.04万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362317
• 关键词: Capsid; Capsid Proteins; DNA; Funding; Grant; National Center for Research Resources; Principal Investigator; Proteolysis; RNA; Radiation; Research; Research Infrastructure; Resources; Roentgen Rays; Signal Transduction; Source; United States National Institutes of Health; Virus; Virus-like particle; cost; member; receptor binding; response; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Virus maturation is often induced by a response to environmental signals like low pH, DNA/RNA packaging and receptor binding. In many cases, they are accompanied by dramatic conformational changes of capsid proteins. Nudaurelia Capensis omega Virus (NV) is a member of Tetravirus, T=4 non-enveloped icosahedral ssRNA viruses. The virus like particles (VLP) of NV coat protein undergo auto-proteolysis after pH-dependent large conformational changes (LCC) induced by lowering the pH (

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 病毒的成熟通常是通过对低pH，DNA/RNA包装和受体结合等环境信号的响应引起的。在许多情况下，它们伴随着衣壳蛋白的急剧构象变化。 Nudaurelia capensis欧米茄病毒（NV）是四病毒的成员，t = 4个非发育的二十面体ssRNA病毒。通过降低pH值诱导的pH依赖性大构象变化（LCC），NV外套蛋白的病毒（VLP）类似于NV外套蛋白（VLP）（VLP）（VLP）（VLP）（VLP）