HIGH RESOLUTION STRUCTURE OF BACTERIOPHAGE P22

噬菌体 P22 的高分辨率结构

• 批准号: 8169661
• 负责人: John Emil Johnson
• 金额: $ 2.33万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169661
• 关键词: Bacteriophage P22; Bacteriophages; Binding Proteins; Capsid; Cells; Computer Retrieval of Information on Scientific Projects Database; DNA; Double Stranded DNA Virus; Enzymes; Event; Funding; Grant; Herpesviridae; Infection; Institution; Molecular Machines; Particle Size; Proteins; Pump; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; particle; pressure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacteriophages, herpesviruses and other large dsDNA viruses contain molecular machines that pump DNA into preassembled procapsids, triggering maturation with an associated cascade of particle size change, release of packaging enzymes, binding of proteins for cell association and activation of the particles for infection. These events are associated with capsid pressures exceeding, by 10-fold, that of bottled champagne, and are detected by a protein switch that transduces a signal from inside to outside of the particle.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 噬菌体，疱疹病毒和其他大型DSDNA病毒含有分子机器，可将DNA泵入预组合的胶囊中，从而触发颗粒大小变化的相关级联，包装酶的释放，蛋白质的结合，用于感染的细胞缔合和颗粒激活。 这些事件与超过10倍瓶装香槟的衣壳压力相关，并通过蛋白质开关检测到，该蛋白质开关从粒子的内部到外部传递信号。