HIGH RESOLUTION STRUCTURE OF BACTERIOPHAGE P22

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 噬菌体、疱疹病毒和其他大型dsDNA病毒含有分子机器，可以将DNA泵入预组装的前壳体中，通过相关的颗粒尺寸变化、包装酶释放、蛋白质结合以进行细胞结合以及颗粒激活以进行感染的级联反应来触发成熟。 这些事件与超过瓶装香槟10倍的衣壳压力有关，并通过将信号从颗粒内部转导到外部的蛋白质开关进行检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacteriophages, herpesviruses and other large dsDNA viruses contain molecular machines that pump DNA into preassembled procapsids, triggering maturation with an associated cascade of particle size change, release of packaging enzymes, binding of proteins for cell association and activation of the particles for infection. These events are associated with capsid pressures exceeding, by 10-fold, that of bottled champagne, and are detected by a protein switch that transduces a signal from inside to outside of the particle.