STRUCTURAL ANALYSIS FOR PROTEINS FROM ARABIDOPSIS THALIANA FAMILY

拟南芥科蛋白质的结构分析

• 批准号: 8168937
• 负责人: JOHN LUTE MARKLEY
• 金额: $ 3.27万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168937
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Development; Family; Funding; Grant; Institution; Methods; Production; Protein Analysis; Protein Dynamics; Proteins; Proteome; Research; Research Personnel; Resources; Solutions; Source; Structure; Technology; Testing; Thale Cress Proteins; United States National Institutes of Health; X-Ray Crystallography; novel; protein folding; structural genomics; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major aims of the Center for Eukaryotic Structural Genomics are the development and critical analysis of methods for high-throughput, proteome-scale, eukaryotic protein production, characterization, and structure determination. This technology is being tested and refined through the determination of crystal and solution state three-dimensional structures of proteins from Arabidopsis thaliana. Particular emphasis is placed on proteins whose sequences suggest that they may contain a novel fold, proteins associated with novel functions, or proteins likely to have a known fold but with a function not previously associated with that fold. It is envisioned that most of the structures will be determined by X-ray crystallography, with NMR used for smaller, more dynamic proteins and for smaller protein targets that fail to crystallize.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 真核结构基因组中心的主要目的是对高通量，蛋白质组规模，真核蛋白质产生，表征和结构测定方法的开发和关键分析。通过确定拟南芥蛋白质的晶体和溶液状态三维结构，正在测试和完善该技术。特别重点放在蛋白质上，其序列表明它们可能包含一种新颖的折叠，与新功能相关的蛋白质或可能具有已知折叠的蛋白质相关的蛋白质，但具有以前与该折叠相关的功能。可以预见的是，大多数结构将由X射线晶体学确定，NMR用于较小的，更动态的蛋白质以及无法结晶的较小蛋白质靶标。