PHYSICAL INFRASTRUCT:ALGORITHMS FOR MODELING LATERAL DIFFUSION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to develop a general algorithm for numerical modeling of diffusion in the cellular membranes. Because geometries in the Virtual Cell are inferred from segmented images, the membrane is approximated by a staircase surface. The key problem therefore is to find an appropriate smoothing algorithm, which allows an accurate approximation of normals and curvatures.