2011 CSHL Yeast Cell Biology Conference

2011年CSHL酵母细胞生物学会议

• 批准号: 8122810
• 负责人: DAVID J. STEWART
• 金额: $ 0.5万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122810
• 关键词: Actins; Alcohols; Animals; Area; Attention; Beds; Biogenesis; Bioinformatics; Biological; Biological Models; Biological Process; Biology; Bread; Candida albicans; Caring; Cell Cycle; Cell Cycle Regulation; Cell division; Cell physiology; Cells; Cellular Structures; Cellular biology; Child; Chromosome Structures; Chromosomes; Collaborations; Communication; Communities; Complement; Computer Simulation; Cytoskeletal Modeling; Cytoskeleton; DNA; Data; Development; Discipline; Disease; Drug Industry; Educational process of instructing; Elements; Ensure; Environment; Eukaryotic Cell; Event; Faculty; Fertilization; Fission Yeast; Fostering; Funding; Future; Genomics; Goals; Health; Human; Individual; Infectious Skin Diseases; Institution; International; Knowledge; Laboratories; Lead; Learning; Life; Membrane Protein Traffic; Methodology; Microscopy; Microtubules; Minority; Molecular; Nuclear; Oral; Organelles; Organism; Participant; Pathway interactions; Physiology; Play; Postdoctoral Fellow; Proteins; Proteomics; Regulation; Relative (related person); Research; Research Institute; Research Personnel; Resource Sharing; Resources; Saccharomyces cerevisiae; Saccharomycetales; Scientist; Senior Scientist; Series; Services; Shapes; Signal Transduction; Signal Transduction Pathway; Structure; Students; Study models; System; Techniques; Technology; Testing; Tissues; Training; Training and Education; Vascular Plant; Woman; Work; Yeasts; abstracting; base; biological research; career; cell type; frontier; fungus; graduate student; insight; interest; meetings; member; next generation; posters; programs; response; role model; skills; success; symposium; tool

DESCRIPTION (provided by applicant): Research in the past decade has spurred tremendous progress in our understanding of molecular mechanisms that underlie cell function. Advances have come from multiple cell types and organisms. Notably, yeast systems often have been at the forefront in the discovery of new proteins, pathways, structures, and in mechanistic insights. Despite its existence as a unicellular organism, yeast research has also revealed unexpected insights into the physiology of multicellular organisms and the functions of specialized tissues. Yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and technologies. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will create a premier forum for the discussion and exchange of cutting-edge discoveries about the internal functions of eukaryotic cells. The program will include eight sessions covering a wide range of topics in cell biology including membrane trafficking, cytoskeleton, the cell cycle, polarity, chromosomes, nuclear organization, and signaling, with a focus on higher order regulation that integrates these diverse events. Each session will be led by two outstanding and well-known investigators in the relevant area. With the exception of short talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other junior investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The meeting will serve to provide a stimulating environment for the free flowing discussion of some of the most exciting data and concepts at the frontiers of knowledge in cell biology. Given the rapid pace of developments in the field, this meeting presents an exciting opportunity for participants to learn about recent breakthroughs that will be relevant to their own research both in yeast and in other systems. The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond yeast cell biology, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights that impact the physiologies of all life forms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions. PUBLIC HEALTH RELEVANCE: Yeast is probably best known for its ability to make bread or alcohol, or perhaps for its ability to cause skin infections and worse. But this humble single-celled organism has become a mainspring of modern biology, because it shares the same principal components and structure as cells of higher plants and animals. This has made yeast a widely studied model for biologists to explore a variety of cellular processes, including how cells grow and divide, how they organize their DNA and chromosomes, how they maintain and organize their organelles, how they move and change shape in response to their environment, and how the sense and respond to external change. In fact work over the last three decades has shown again and again that even at the molecular level, yeast cells share many components and details with their more "sophisticated" cousins. The relative simplicity of yeast means that a huge body of knowledge about its biology has been accumulated, and many molecular tools and approaches were first developed and are at their most complicated in the analysis of these cells. It is also becoming more evident just how much apparently unrelated functions are actually highly coordinated and orchestrated, requiring a more holistic exploration of cell function to understand how individual parts work together. Because of the implications on biology in other systems, including in human health and disease, yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and techniques. This proposed meeting series, long the forum for scientists to present their latest unpublished ideas, aims to keep the yeast system as an important and useful model system by promoting rapid dissemination of advances and open communication between experts in various disciplines. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will continue a premier forum for the discussion and exchange of cutting-edge discoveries, attract and allow the active participation of a diverse group of scientists, and will help to accelerate biological research with real and well-proven implications for human well being.

描述(由申请人提供)：过去十年的研究促进了我们对构成细胞功能的分子机制的理解的巨大进步。进展来自多种细胞类型和生物体。值得注意的是，酵母系统在发现新的蛋白质、途径、结构和机械洞察方面往往走在了前列。尽管酵母作为单细胞生物体存在，但对多细胞生物体的生理学和特殊组织的功能的研究也揭示了意想不到的见解。酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统作为新概念和新技术的试验台，对更大的研究社区至关重要。酵母细胞生物学系列会议(2011、2013和2015)的学术价值在于，它将为讨论和交流关于真核细胞内部功能的前沿发现创造一个主要论坛。该计划将包括八个课程，涵盖细胞生物学的广泛主题，包括膜运输、细胞骨架、细胞周期、极性、染色体、核组织和信号传递，重点是整合这些不同事件的更高级别的调控。每一次会议将由相关领域的两名杰出和知名的调查人员领导。除了会议主席发表的简短演讲外，所有的演讲和海报都将从提交的摘要中挑选出来，大部分演讲将由学生、博士后研究员和其他初级研究人员进行。预计将有超过275名科学家参加。其中，超过一半的人可能是研究生和博士后研究员。这次会议将为在细胞生物学知识前沿对一些最令人兴奋的数据和概念进行自由流动的讨论提供一个刺激的环境。鉴于该领域的快速发展，这次会议为与会者提供了一个令人兴奋的机会，让他们了解最近的突破，这些突破将与他们自己在酵母和其他系统中的研究相关。拟议活动的更广泛影响是多方面的。首先，它们包括对酵母细胞生物学以外的其他领域的科学影响，因为该领域的发现将继续促进影响所有生命形式的生理学的基本发现和见解的快速发展。其次，它们还包括教育、培训、资源共享以及互动和合作机会等要素。尤其是，会议将提供：(1)为初级科学家提供培训机会，以促进陈述技能的发展以及整体科学素质和分析的严谨性；(2)为所有职业级别的科学家提供一个促进有意义的科学互动的亲密环境；(3)在多层次的研究和教育机构中传播知识；(4)共享材料和信息资源；以及(V)开展合作的机会，这可以使来自较小实验室和/或主要来自本科(教学)机构的科学家受益，这些机构可能比主要研究机构的科学家拥有更少的资源和更有限的机会获得尖端技术。 与公众健康相关：酵母最为人所知的可能是它制造面包或酒精的能力，或者它可能导致皮肤感染和更糟的能力。但这种不起眼的单细胞有机体已经成为现代生物学的主要来源，因为它与高等动植物细胞具有相同的主要成分和结构。这使得酵母成为生物学家探索各种细胞过程的广泛研究模型，包括细胞如何生长和分裂，它们如何组织DNA和染色体，它们如何维持和组织它们的细胞器，它们如何随着环境移动和改变形状，以及细胞如何感知和响应外部变化。事实上，过去三十年的研究一次又一次地表明，即使在分子水平上，酵母细胞也与它们更“复杂”的近亲有许多共同的成分和细节。酵母的相对简单意味着已经积累了大量关于其生物学的知识，许多分子工具和方法最先被开发出来，并且在这些细胞的分析中处于最复杂的状态。也变得越来越明显的是，有多少表面上不相关的功能实际上是高度协调和协调的，这需要对细胞功能进行更全面的探索，以了解各个部分是如何协同工作的。由于酵母细胞生物学对其他系统生物学的影响，包括对人类健康和疾病的影响，酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统作为新概念和新技术的试验台，对更大的研究社区至关重要。这个拟议的会议系列长期以来一直是科学家展示他们最新未发表观点的论坛，旨在通过促进不同学科专家之间的进展和开放交流，保持酵母系统作为一个重要和有用的模式系统。酵母细胞生物学系列会议(2011年、2013年和2015年)的学术价值在于，它将继续成为讨论和交流尖端发现的主要论坛，吸引并允许不同科学家群体的积极参与，并将有助于加快对人类福祉具有真正和充分证明的影响的生物研究。