2011 CSHL Yeast Cell Biology Conference

描述（由申请人提供）：过去十年的研究促使我们在理解细胞功能的分子机制方面取得了巨大进展。进步来自多种细胞类型和生物体。值得注意的是，酵母系统通常处于发现新蛋白质、途径、结构和机械见解的最前沿。尽管酵母是一种单细胞生物，但它的研究也揭示了对多细胞生物生理学和专门组织功能的意想不到的见解。酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统作为新概念和新技术的试验平台，对更大的研究界至关重要。酵母细胞生物学系列会议（2011年，2013年和2015年）的智力价值在于，它将为讨论和交流有关真核细胞内部功能的前沿发现创造一个首要论坛。该计划将包括八个会议，涵盖细胞生物学的广泛主题，包括膜运输，细胞骨架，细胞周期，极性，染色体，核组织和信号，重点是整合这些不同事件的高阶调控。每次会议将由相关领域的两名杰出和知名调查员主持。除了会议主席提出的简短演讲外，所有演讲和海报都将从提交的摘要中选出，大部分演讲将由学生，博士后研究员和其他初级研究人员提供。预计将有超过275名科学家参加。其中，一半以上可能是研究生和博士后研究员。会议将为细胞生物学知识前沿的一些最令人兴奋的数据和概念的自由流动的讨论提供一个刺激的环境。鉴于该领域的快速发展，本次会议为与会者提供了一个令人兴奋的机会，了解与他们自己在酵母和其他系统中的研究相关的最新突破。拟议活动的广泛影响是多方面的。首先，它们包括对酵母细胞生物学以外其他领域的科学影响，因为这一领域的发现将继续促进影响所有生命形式生理学的基础发现和见解的快速发展。其次，它们还包括教育、培训、资源共享以及互动和合作机会等要素。特别是，会议将提供：㈠为年轻科学家提供培训机会，以促进发展演讲技巧以及全面的科学素质和分析严谨性; ㈡提供一个亲密的环境，以促进所有职业层次的科学家之间有意义的科学互动; ㈢在研究和教育机构的多个层次之间传播知识;（iv）分享物质和信息资源;（v）提供开展合作的机会，这可使来自小型实验室和/或主要来自本科（教学）机构的科学家受益，他们的资源可能比来自大型研究机构的科学家少，接触尖端技术的机会也更有限。 公共卫生相关性：酵母菌最为人所知的可能是它能够制造面包或酒精，或者可能是它能够引起皮肤感染和更糟的情况。但这种不起眼的单细胞生物体却成为现代生物学的主要推动力，因为它与高等植物和动物的细胞具有相同的主要成分和结构。这使得酵母成为生物学家广泛研究的模型，用于探索各种细胞过程，包括细胞如何生长和分裂，如何组织DNA和染色体，如何维持和组织细胞器，如何移动和改变形状以应对环境，以及如何感知和应对外部变化。事实上，过去三十年的研究一再表明，即使在分子水平上，酵母细胞也与它们更“复杂”的表亲共享许多成分和细节。酵母的相对简单性意味着已经积累了大量关于其生物学的知识，许多分子工具和方法首先被开发出来，并且在这些细胞的分析中最为复杂。越来越明显的是，有多少看似无关的功能实际上是高度协调和精心安排的，这需要对细胞功能进行更全面的探索，以了解各个部分如何协同工作。由于酵母细胞生物学对其他系统（包括人类健康和疾病）中的生物学的影响，酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统作为新概念和技术的试验平台，对更大的研究界至关重要。这一拟议的会议系列，长期以来一直是科学家们展示他们最新未发表想法的论坛，旨在通过促进各学科专家之间的进展和开放交流的快速传播，使酵母系统成为重要和有用的模型系统。关于酵母细胞生物学的会议系列（2011年，2013年和2015年）的智力价值在于，它将继续成为讨论和交流前沿发现的首要论坛，吸引并允许不同科学家群体的积极参与，并将有助于加速生物研究，对人类福祉产生真实的和经过充分验证的影响。

DESCRIPTION (provided by applicant): Research in the past decade has spurred tremendous progress in our understanding of molecular mechanisms that underlie cell function. Advances have come from multiple cell types and organisms. Notably, yeast systems often have been at the forefront in the discovery of new proteins, pathways, structures, and in mechanistic insights. Despite its existence as a unicellular organism, yeast research has also revealed unexpected insights into the physiology of multicellular organisms and the functions of specialized tissues. Yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and technologies. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will create a premier forum for the discussion and exchange of cutting-edge discoveries about the internal functions of eukaryotic cells. The program will include eight sessions covering a wide range of topics in cell biology including membrane trafficking, cytoskeleton, the cell cycle, polarity, chromosomes, nuclear organization, and signaling, with a focus on higher order regulation that integrates these diverse events. Each session will be led by two outstanding and well-known investigators in the relevant area. With the exception of short talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other junior investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The meeting will serve to provide a stimulating environment for the free flowing discussion of some of the most exciting data and concepts at the frontiers of knowledge in cell biology. Given the rapid pace of developments in the field, this meeting presents an exciting opportunity for participants to learn about recent breakthroughs that will be relevant to their own research both in yeast and in other systems. The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond yeast cell biology, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights that impact the physiologies of all life forms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions. PUBLIC HEALTH RELEVANCE: Yeast is probably best known for its ability to make bread or alcohol, or perhaps for its ability to cause skin infections and worse. But this humble single-celled organism has become a mainspring of modern biology, because it shares the same principal components and structure as cells of higher plants and animals. This has made yeast a widely studied model for biologists to explore a variety of cellular processes, including how cells grow and divide, how they organize their DNA and chromosomes, how they maintain and organize their organelles, how they move and change shape in response to their environment, and how the sense and respond to external change. In fact work over the last three decades has shown again and again that even at the molecular level, yeast cells share many components and details with their more "sophisticated" cousins. The relative simplicity of yeast means that a huge body of knowledge about its biology has been accumulated, and many molecular tools and approaches were first developed and are at their most complicated in the analysis of these cells. It is also becoming more evident just how much apparently unrelated functions are actually highly coordinated and orchestrated, requiring a more holistic exploration of cell function to understand how individual parts work together. Because of the implications on biology in other systems, including in human health and disease, yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and techniques. This proposed meeting series, long the forum for scientists to present their latest unpublished ideas, aims to keep the yeast system as an important and useful model system by promoting rapid dissemination of advances and open communication between experts in various disciplines. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will continue a premier forum for the discussion and exchange of cutting-edge discoveries, attract and allow the active participation of a diverse group of scientists, and will help to accelerate biological research with real and well-proven implications for human well being.