X-RAY CRYSTALLOGRAPHY

X射线晶体学核心的主要目标是实现和促进MSKCC的研究 这些实验室使用X射线晶体学作为工具来解决其研究项目中的问题。的 设施维护用于数据收集、处理和结构确定的内部设备， 广泛的晶体学和结构分析软件包，提供长期的定期 通过参与两个多机构联盟获得最先进的同步加速器光束线 国家实验室地点，为内部和 远程设施，并提供专业知识，结构生物学和建模和指导非结构 MSKCC实验室受益于在设计和解释中使用可用结构， 实验 结构生物学在理解许多生物学过程中起着越来越重要的作用 在癌症和加快抗癌药物发现的步伐方面很重要。在后基因组时代， 需要结构数据来理解生物功能和调节，为设计提供支架 或改善候选抗癌化合物，并帮助确定分子功能将随着 大规模并行数据采集工具的应用，如DMA阵列，全局蛋白质-蛋白质 相互作用图谱和癌症相关基因的大规模鉴定。这将需要增加 传统X射线晶体学设备和最先进的同步加速器设备的吞吐量 加速结构确定，并允许研究越来越大和复杂的结构， 大分子组装体

The primary goal of the X-ray Crystallography Core is to enable and facilitate the research of MSKCC laboratories that use X-ray crystallography as a tool to address questions in their research programs. The facility maintains in-house equipment for data collection, processing and structure determination, implements a wide range of crystallographic and structure analysis software packages, provides long-term regular access to state-of-the-art synchrotron beamlines through participation in multi-institutional consortia at two national laboratory locations, provides training and technical assistance to users of both the in-house and remote facilities, and provides expertise in structural biology and modeling and guidance to non-structural MSKCC laboratories that benefit from the use of available structures in the design and interpretation of experiments. Structural biology has been playing an increasing role in understanding the many biological processes important in cancer and in accelerating the pace of anti-cancer drug discovery. In the post-genomic era, the need for structural data to understand biological function and regulation, to provide scaffolds for the design or improvement of candidate anticancer compounds, and to help identify molecular function will increase with the application of massively parallel data acquisition tools such as DMA arrays, global protein-protein interaction maps and large scale identification of cancer-related genes. This will require increased throughput from conventional X-ray crystallography facilities, and new, state-of-the-art synchrotron facilities to accelerate structure determination and to allow the study of increasingly large and complex structures and macromolecular assemblies.