CAMs as counter measures against infectious and inflammatory disease

CAM 作为对抗传染病和炎症性疾病的对策

• 批准号: 8302174
• 负责人: Mark A Jutila
• 金额: $ 115.26万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302174
• 关键词: Accounting; Address; Agonist; Animal Experiments; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Arthritis; Bacterial Infections; Cell physiology; Centers of Research Excellence; Collaborations; Communicable Diseases; Disease; Doctor of Philosophy; Ensure; Epithelial Cells; Fostering; Goals; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Intestinal Mucosa; Intestines; Leukocytes; Lung; Measures; Modeling; Molecular; National Center for Complementary and Alternative Medicine; Pathology; Plant Extracts; Prevention; Probiotics; Reporting; Research Project Grants; Resources; Rodent; Rodent Model; Safety; Scientist; Services; T-Lymphocyte; Tissues; Training; Viral; Virus Diseases; animal model development; base; biosafety level 3 facility; insight; meetings; microbial

DESCRIPTION (provided by applicant): CAMs are used for the prevention and treatment of infectious and inflammatory diseases, though for many of these CAMs, their true efficacy and the molecular basis for their purported benefits have not been defined and/or confirmed. We propose a new Center of Excellence for Research on CAMs (CERC) focused on the study of the mechanisms of action of diverse CAMs in models of pulmonary and intestinal infectious disease. Since in many instances the resulting inflammatory response associated with infection in the lung and intestinal track accounts for the actual pathology in the disease, we also intend to expand ongoing efforts in using CAMs to minimize inflammation induced tissue damage. The ultimate goal of this CERC is to provide critical insight into the mechanisms of action of select CAMs that can be used as countermeasures against emerging and select agents that infect the pulmonary and intestinal mucosa. This Center brings together scientists with expertise in bacterial and viral diseases of the lung and intestinal tract, study of CAM effects on innate leukocytes and epithelial cells, purification of defined agonists from crude plant extracts, use of probiotic CAMs, and use of rodent models of infectious and inflammatory disease to define specific mechanisms of action. This Center will also take advantage of new BSL-3 facilities to study the impact of CAMs on select agents. The CERC will initially be focused on three distinct projects, which will be supported by two Cores: Administrative (Core A) and Animal Model (Core B). The three Research Projects are: Project 1) CAMs that enhance ??T cell function, Project Leader, Mark Jutila, Ph.D.; Project 2) Anti-viral CAMs, Project Leader, Dr. Michele Hardy, Ph.D.; and Project 3) Anti-inflammatory microbial CAMs and arthritis, Project Leader, Dr. David Pascual, Ph.D. The Animal Models Core will serve as a unique and highly interactive resource, facilitating synergy and collaboration between the three research projects.

描述（由申请人提供）：CAM 用于预防和治疗传染性和炎症性疾病，尽管对于许多此类 CAM，其真正功效及其声称的益处的分子基础尚未确定和/或证实。我们提议建立一个新的 CAM 卓越研究中心 (CERC)，重点研究不同 CAM 在肺部和肠道传染病模型中的作用机制。由于在许多情况下，与肺部和肠道感染相关的炎症反应是疾病的实际病理原因，因此我们还打算扩大使用 CAM 的持续努力，以尽量减少炎症引起的组织损伤。该 CERC 的最终目标是提供对特定 CAM 作用机制的重要见解，这些机制可用作针对感染肺和肠粘膜的新兴和特定病原体的对策。该中心汇集了在肺和肠道细菌和病毒疾病、CAM 对先天白细胞和上皮细胞的影响、从粗植物提取物中纯化特定激动剂、益生菌 CAM 的使用以及使用感染和炎症性疾病的啮齿动物模型来定义特定作用机制方面具有专业知识的科学家。该中心还将利用新的 BSL-3 设施来研究 CAM 对选定代理人的影响。 CERC 最初将重点关注三个不同的项目，这些项目将得到两个核心的支持：行政（核心 A）和动物模型（核心 B）。这三个研究项目是：项目1）增强T细胞功能的CAM，项目负责人，Mark Jutila博士；项目2）抗病毒CAM，项目负责人，Michele Hardy博士；项目 3) 抗炎微生物 CAM 和关节炎，项目负责人 David Pascual 博士。动物模型核心将作为独特且高度互动的资源，促进三个研究项目之间的协同与合作。

项目成果

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

• DOI: 10.1016/j.intimp.2013.01.015
• 发表时间: 2013-03
• 期刊: International immunopharmacology
• 影响因子: 5.6
• 作者: Schepetkin IA;Kouakou K;Yapi A;Kirpotina LN;Jutila MA;Quinn MT
• 通讯作者: Quinn MT

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.

• DOI: 10.1016/j.intimp.2015.04.008
• 发表时间: 2015-06
• 期刊: International immunopharmacology
• 影响因子: 5.6
• 作者: Ramstead AG;Schepetkin IA;Todd K;Loeffelholz J;Berardinelli JG;Quinn MT;Jutila MA
• 通讯作者: Jutila MA

Milk-based nutraceutical for treating autoimmune arthritis via the stimulation of IL-10- and TGF-β-producing CD39+ regulatory T cells.

• DOI: 10.1371/journal.pone.0117825
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Maddaloni M;Kochetkova I;Jun S;Callis G;Thornburg T;Pascual DW
• 通讯作者: Pascual DW

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

• DOI: 10.1016/j.jep.2012.12.037
• 发表时间: 2013-03-07
• 期刊: JOURNAL OF ETHNOPHARMACOLOGY
• 影响因子: 5.4
• 作者: Kouakou, Koffi;Schepetkin, Igor A.;Yapi, Ahoua;Kirpotina, Liliya N.;Jutila, Mark A.;Quinn, Mark T.
• 通讯作者: Quinn, Mark T.

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.

• DOI: 10.1186/1472-6882-13-149
• 发表时间: 2013-06-28
• 期刊: BMC complementary and alternative medicine
• 作者: Kouakou K;Schepetkin IA;Jun S;Kirpotina LN;Yapi A;Khramova DS;Pascual DW;Ovodov YS;Jutila MA;Quinn MT
• 通讯作者: Quinn MT