CAMs as counter measures against infectious and inflammatory disease

CAM 作为对抗传染病和炎症性疾病的对策

• 批准号: 8302174
• 负责人: Mark A Jutila
• 金额: $ 115.26万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302174
• 关键词: Accounting; Address; Agonist; Animal Experiments; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Arthritis; Bacterial Infections; Cell physiology; Centers of Research Excellence; Collaborations; Communicable Diseases; Disease; Doctor of Philosophy; Ensure; Epithelial Cells; Fostering; Goals; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Intestinal Mucosa; Intestines; Leukocytes; Lung; Measures; Modeling; Molecular; National Center for Complementary and Alternative Medicine; Pathology; Plant Extracts; Prevention; Probiotics; Reporting; Research Project Grants; Resources; Rodent; Rodent Model; Safety; Scientist; Services; T-Lymphocyte; Tissues; Training; Viral; Virus Diseases; animal model development; base; biosafety level 3 facility; insight; meetings; microbial

DESCRIPTION (provided by applicant): CAMs are used for the prevention and treatment of infectious and inflammatory diseases, though for many of these CAMs, their true efficacy and the molecular basis for their purported benefits have not been defined and/or confirmed. We propose a new Center of Excellence for Research on CAMs (CERC) focused on the study of the mechanisms of action of diverse CAMs in models of pulmonary and intestinal infectious disease. Since in many instances the resulting inflammatory response associated with infection in the lung and intestinal track accounts for the actual pathology in the disease, we also intend to expand ongoing efforts in using CAMs to minimize inflammation induced tissue damage. The ultimate goal of this CERC is to provide critical insight into the mechanisms of action of select CAMs that can be used as countermeasures against emerging and select agents that infect the pulmonary and intestinal mucosa. This Center brings together scientists with expertise in bacterial and viral diseases of the lung and intestinal tract, study of CAM effects on innate leukocytes and epithelial cells, purification of defined agonists from crude plant extracts, use of probiotic CAMs, and use of rodent models of infectious and inflammatory disease to define specific mechanisms of action. This Center will also take advantage of new BSL-3 facilities to study the impact of CAMs on select agents. The CERC will initially be focused on three distinct projects, which will be supported by two Cores: Administrative (Core A) and Animal Model (Core B). The three Research Projects are: Project 1) CAMs that enhance ??T cell function, Project Leader, Mark Jutila, Ph.D.; Project 2) Anti-viral CAMs, Project Leader, Dr. Michele Hardy, Ph.D.; and Project 3) Anti-inflammatory microbial CAMs and arthritis, Project Leader, Dr. David Pascual, Ph.D. The Animal Models Core will serve as a unique and highly interactive resource, facilitating synergy and collaboration between the three research projects.

描述（由申请人提供）：CAM用于预防和治疗感染性和炎性疾病，尽管对于许多这些CAM，其真正的疗效和其声称的益处的分子基础尚未被定义和/或证实。我们提出了一个新的卓越中心的研究CAM（CERC）的重点是不同的CAM在肺部和肠道传染病模型的作用机制的研究。由于在许多情况下，与肺部和肠道感染相关的炎症反应导致了疾病的实际病理学，因此我们还打算扩大使用CAM的持续努力，以最大限度地减少炎症诱导的组织损伤。该CERC的最终目标是提供对选择CAM的作用机制的关键见解，这些CAM可用作对抗感染肺和肠粘膜的新出现和选择因子的对策。该中心汇集了在肺部和肠道的细菌和病毒疾病，CAM对先天性白细胞和上皮细胞的影响，从天然植物提取物中纯化确定的激动剂，使用益生菌CAM，以及使用感染性和炎症性疾病的啮齿动物模型来确定特定作用机制方面具有专业知识的科学家。该中心还将利用新的BSL-3设施来研究CAM对特定代理人的影响。CERC最初将集中在三个不同的项目上，这三个项目将由两个核心支持：管理（核心A）和动物模型（核心B）。这三个研究项目是：项目1）CAM，提高？？T细胞功能，项目负责人，Mark Jutila博士;项目2）抗病毒CAMs，项目负责人，Dr. Michele哈代，Ph.D.;和项目3）抗炎微生物CAM和关节炎，项目负责人，大卫帕斯夸尔博士，博士。动物模型核心将作为一个独特的和高度互动的资源，促进三个研究项目之间的协同作用和合作。

项目成果

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

• DOI: 10.1016/j.intimp.2013.01.015
• 发表时间: 2013-03
• 期刊: International immunopharmacology
• 影响因子: 5.6
• 作者: Schepetkin IA;Kouakou K;Yapi A;Kirpotina LN;Jutila MA;Quinn MT
• 通讯作者: Quinn MT

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.

• DOI: 10.1016/j.intimp.2015.04.008
• 发表时间: 2015-06
• 期刊: International immunopharmacology
• 影响因子: 5.6
• 作者: Ramstead AG;Schepetkin IA;Todd K;Loeffelholz J;Berardinelli JG;Quinn MT;Jutila MA
• 通讯作者: Jutila MA

Milk-based nutraceutical for treating autoimmune arthritis via the stimulation of IL-10- and TGF-β-producing CD39+ regulatory T cells.

• DOI: 10.1371/journal.pone.0117825
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Maddaloni M;Kochetkova I;Jun S;Callis G;Thornburg T;Pascual DW
• 通讯作者: Pascual DW

Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

• DOI: 10.1016/j.jep.2012.12.037
• 发表时间: 2013-03-07
• 期刊: JOURNAL OF ETHNOPHARMACOLOGY
• 影响因子: 5.4
• 作者: Kouakou, Koffi;Schepetkin, Igor A.;Yapi, Ahoua;Kirpotina, Liliya N.;Jutila, Mark A.;Quinn, Mark T.
• 通讯作者: Quinn, Mark T.

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.

• DOI: 10.1186/1472-6882-13-149
• 发表时间: 2013-06-28
• 期刊: BMC complementary and alternative medicine
• 作者: Kouakou K;Schepetkin IA;Jun S;Kirpotina LN;Yapi A;Khramova DS;Pascual DW;Ovodov YS;Jutila MA;Quinn MT
• 通讯作者: Quinn MT