Genomics

基因组学

• 批准号: 8279422
• 负责人: George S Watts
• 金额: $ 15.57万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8279422
• 关键词: Arizona; Cancer Center; Cancer Center Support Grant; Client satisfaction; Cognitive; Consultations; Custom; DNA; DNA Methylation; DNA Resequencing; Data; Diagnostic; Experimental Designs; Gene Expression; Genomics; Housing; Interview; Language; Mental Depression; Microarray Analysis; Mission; Nucleic Acids; Patients; Perinatal; Phase; Postpartum Depression; Postpartum Women; Preparation; Private Sector; Protocols documentation; Public Sector; Quality Control; Research Personnel; Research Project Grants; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Scanning; Services; Site; Source; Surveys; Symptoms; Techniques; Technology; Testing; Time; Update; Woman; base; cost; depressive symptoms; experience; high throughput analysis; response; sound; time use

Estimates of antenatal and postpartum depression vary from 7% to upwards of 30% depending on criteria for depression, the type of assessment used, and the timing of the assessment. Thus, approximately 320,000 to over 1 million women each year experience symptoms of perinatal depression. Estimates of antenatal depression are harder to obtain because of the lack of appropriate diagnostic criteria. Despite this, no screener currently exists that has been developed and tested with both antenatal and postpartum women that uses concise, simple language, and a consistent response option set. The overall aim of this project is to develop a brief screener to assess depressive symptoms among antenatal and postpartum women. The proposed screener will be easier for patients to understand, will take less time, and will be more psychometrically sound than current screeners. In Phase I we will develop approximately 30 items that are specific to depression in antenatal and postpartum women. We will test these items using cognitive interviewing among a sample of 10 antenatal and 10 postpartum women in addition to 32 general depression items we have previously developed. Experts will review the results of the cognitive interviewing to develop the item pool that will be tested in Phase II. The Phase II item pool will consist of at least 20 general depression items, 10 items specific to antenatal women, and 10 items specific to postpartum women. In Phase II, 500 antenatal and 500 postpartum women (70% from private sector sites and 30% from public sector sites) will complete the EPDS (as a screener into the study), BDI-II, the PROMIS depression items, our items, and the depression module of the SCID. IRT analyses will be conducted on these data to develop a 7-9 item screener. We anticipate that approximately 5-7 of these items will be applicable to both antenatal and postpartum women and approximately 2-3 of these items will be sample specific. The developed screener will then be given to 400 women who will take the survey twice, approximately 4-7 days apart. Conclusions regarding test-retest reliability and patient satisfaction with taking the screener using different modes of technologies will be made from this study.

产前和产后抑郁症的估计从7%到30%以上不等 根据抑郁症的标准、使用的评估类型和评估的时间， 考核因此，每年约有32万至100多万妇女 经历围产期抑郁症的症状。产前抑郁症的估计是 由于缺乏适当的诊断标准，很难获得。尽管如此，没有 目前存在的筛选器已经开发并测试了产前和 产后妇女使用简洁，简单的语言，和一致的反应， 选项集。 这个项目的总体目标是开发一个简短的筛选器来评估抑郁症 产前和产后妇女的症状。建议的筛选器将是 患者更容易理解，花费的时间更少，并且在心理测量上更容易 比目前的屏幕。 在第一阶段，我们将开发大约30个项目，具体到抑郁症， 产前和产后妇女。我们将使用认知访谈来测试这些项目 在10名产前和10名产后妇女的样本中， 我们以前开发的抑郁症项目。专家们将审查结果， 认知访谈，以开发将在第二阶段测试的项目库。相位 II项目库将包括至少20个一般抑郁症项目，10个特定于 产前妇女和产后妇女特有的10个项目。 在第二阶段，500名产前妇女和500名产后妇女（70%来自私营部门地点 30%来自公共部门站点）将完成EPDS（作为研究的筛选者）， BDI-II、PROMIS抑郁症项目、我们的项目和 SCID。将对这些数据进行IRT分析，以开发7 - 9项筛选器。我们 预计这些项目中约有5 - 7项将适用于产前和产后护理， 产后妇女和大约2 - 3个这些项目将是样本特异性的。的 然后将开发的筛选器提供给400名妇女，她们将接受两次调查， 间隔大约4 - 7天。关于重测可靠性和患者的结论 使用不同模式的技术进行筛选将获得满意度 从这项研究中。