Genomics

基因组学

• 批准号: 8540939
• 负责人: George S Watts
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540939
• 关键词: Arizona; Cancer Center; Cancer Center Support Grant; ChIP-on-chip; Client satisfaction; Cognitive; Consultations; Custom; DNA; DNA Methylation; DNA Resequencing; Data; Diagnostic; Experimental Designs; Gene Expression Profiling; Genomics; Housing; Interview; Language; Mental Depression; Microarray Analysis; Mission; Nucleic Acids; Patients; Perinatal; Phase; Postpartum Depression; Postpartum Women; Preparation; Private Sector; Protocols documentation; Public Sector; Quality Control; Research Personnel; Research Project Grants; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Scanning; Services; Site; Source; Surveys; Symptoms; Techniques; Technology; Testing; Time; Update; Woman; base; cost; depressive symptoms; experience; high throughput analysis; response; sound; time use

Estimates of antenatal and postpartum depression vary from 7% to upwards of 30% depending on criteria for depression, the type of assessment used, and the timing of the assessment. Thus, approximately 320,000 to over 1 million women each year experience symptoms of perinatal depression. Estimates of antenatal depression are harder to obtain because of the lack of appropriate diagnostic criteria. Despite this, no screener currently exists that has been developed and tested with both antenatal and postpartum women that uses concise, simple language, and a consistent response option set. The overall aim of this project is to develop a brief screener to assess depressive symptoms among antenatal and postpartum women. The proposed screener will be easier for patients to understand, will take less time, and will be more psychometrically sound than current screeners. In Phase I we will develop approximately 30 items that are specific to depression in antenatal and postpartum women. We will test these items using cognitive interviewing among a sample of 10 antenatal and 10 postpartum women in addition to 32 general depression items we have previously developed. Experts will review the results of the cognitive interviewing to develop the item pool that will be tested in Phase II. The Phase II item pool will consist of at least 20 general depression items, 10 items specific to antenatal women, and 10 items specific to postpartum women. In Phase II, 500 antenatal and 500 postpartum women (70% from private sector sites and 30% from public sector sites) will complete the EPDS (as a screener into the study), BDI-II, the PROMIS depression items, our items, and the depression module of the SCID. IRT analyses will be conducted on these data to develop a 7-9 item screener. We anticipate that approximately 5-7 of these items will be applicable to both antenatal and postpartum women and approximately 2-3 of these items will be sample specific. The developed screener will then be given to 400 women who will take the survey twice, approximately 4-7 days apart. Conclusions regarding test-retest reliability and patient satisfaction with taking the screener using different modes of technologies will be made from this study.

产前和产后抑郁症的估计从7%到30%以上不等