NF-kappaB Signaling and Biology: From Bench to Bedside

说明： 本应用程序请求支持将于2012年3月18日至23日在加拿大不列颠哥伦比亚省举行的名为NF-kappaB信号和生物学：从工作台到床边的Keystone研讨会，该会议由Michael Karin和Hao Wu组织。多年来，核因子-kappaB的调节和功能一直吸引着分子和细胞生物学家以及免疫学家、病理学家和药物研发人员的兴趣。对核因子-kappaB及其调控的研究给我们在基础生物科学和生物医学中提供了许多基本的教训和原理。尽管在发现25年后，NF-kappaB油田迅速成熟，但它仍然充满活力和肥沃，从未停止过对新的开创性发现的惊叹。关于核因子-kappaB信号和生物学的关键研讨会：从工作台到床边将涵盖核因子-kappaB信号的基本生物化学，核因子-kappaB如何完成其作为转录因子的主要工作，核因子-kappaB系统在免疫和炎症中的作用，核因子-kappaB如何控制细胞死亡、存活和新陈代谢，以及所有这些功能如何在疾病发展过程中出错-这是我们从对转基因小鼠的研究以及从人类遗传缺陷和病理学的研究中了解到的。最后，这次会议将教我们如何通过对核因子-kappaB系统的药理学靶向来修复和治愈这些问题。同时举行的泛素信号会议将大大增加跨学科互动的机会，该会议将与本次会议举行一次主旨演讲和三次全体会议。 公共卫生相关性： 核因子-kappaB转录因子是免疫和炎症反应的主要调节因子，当解除调控时，这些反应是癌症、炎症性疾病以及免疫系统以外疾病的重要原因。关于核因子-kappaB信号和生物学的Keystone研讨会：从长凳到床边将研究我们如何通过针对核因子-kappaB系统的药理学靶向来修复和治愈这些问题。

DESCRIPTION: This application requests support for a Keystone Symposia meeting entitled NF-kappaB Signaling and Biology: From Bench to Bedside, organized by Michael Karin and Hao Wu, which will be held in British Columbia, Canada from March 18-23, 2012. The regulation and function of NF-kappaB have captivated molecular and cellular biologists, as well as immunologists, pathologists and drug developers for many years. Studies of NF-kappaB and its regulation have taught us many fundamental lessons and principals in basic biological sciences as well as in biomedicine. Although rapidly reaching maturity, with 25 years since its discovery, the NF-kappaB field remains vibrant and fertile, and never ceases to amaze with new groundbreaking discoveries. The Keystone Symposia meeting on NF-kappaB Signaling and Biology: From Bench to Bedside will cover the basic biochemistry of NF-kappaB signaling, how NF-kappaB accomplishes its main job as a transcription factor, the roles of the NF-kappaB system in immunity and inflammation, how NF-kappaB controls cell death, survival and metabolism, and how all of these functions go awry during disease development - something that we have learned both from studies of genetically altered mice and from studies of human genetic defects and pathology. Finally, this meeting will teach us how we might fix and cure these problems through the pharmacological targeting of the NF-kappaB system. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Ubiquitin Signaling, which will share a keynote address and three plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: NF-kappaB transcription factors are master regulators of immune and inflammatory responses which, when deregulated, are important causes of cancer, inflammatory diseases as well as diseases outside the immune system. The Keystone Symposia meeting on NF-kappaB Signaling and Biology: From Bench to Bedside will examine how we might fix and cure these problems through the pharmacological targeting of the NF-kappaB system.