NF-kappaB Signaling and Biology: From Bench to Bedside

产品说明： 本申请请求支持将于2012年3月18日至23日在加拿大不列颠哥伦比亚省举行的由Michael Karin和Hao Wu组织的名为NF-κ B信号传导和生物学：从实验室到临床的Keystone研讨会会议。多年来，NF-κ B的调控和功能一直吸引着分子和细胞生物学家，以及免疫学家，病理学家和药物开发人员。对NF-κ B及其调控的研究已经教会了我们许多基础生物科学和生物医学的基本经验和原则。尽管NF-kappaB领域在发现25年后迅速成熟，但它仍然充满活力和肥沃，并且从未停止过新的突破性发现。关于NF-κ B信号传导和生物学的Keystone研讨会：从实验室到床边将涵盖NF-κ B信号传导的基本生物化学，NF-κ B如何完成其作为转录因子的主要工作，NF-κ B系统在免疫和炎症中的作用，NF-κ B如何控制细胞死亡，存活和代谢，以及在疾病发展过程中这些功能是如何出错的--这是我们从对转基因小鼠的研究和对人类遗传缺陷和病理学的研究中了解到的。最后，这次会议将教我们如何通过NF-κ B系统的药理学靶向来修复和治愈这些问题。跨学科互动的机会将显着提高了同时举行的会议上泛素信号，这将与本次会议分享一个主题演讲和三个全体会议。 公共卫生相关性： NF-κ B转录因子是免疫和炎症反应的主要调节因子，当其被解除调节时，是癌症、炎性疾病以及免疫系统外疾病的重要原因。关于NF-κ B信号传导和生物学的Keystone研讨会会议：从实验室到床边将研究我们如何通过NF-κ B系统的药理学靶向来解决和治愈这些问题。

DESCRIPTION: This application requests support for a Keystone Symposia meeting entitled NF-kappaB Signaling and Biology: From Bench to Bedside, organized by Michael Karin and Hao Wu, which will be held in British Columbia, Canada from March 18-23, 2012. The regulation and function of NF-kappaB have captivated molecular and cellular biologists, as well as immunologists, pathologists and drug developers for many years. Studies of NF-kappaB and its regulation have taught us many fundamental lessons and principals in basic biological sciences as well as in biomedicine. Although rapidly reaching maturity, with 25 years since its discovery, the NF-kappaB field remains vibrant and fertile, and never ceases to amaze with new groundbreaking discoveries. The Keystone Symposia meeting on NF-kappaB Signaling and Biology: From Bench to Bedside will cover the basic biochemistry of NF-kappaB signaling, how NF-kappaB accomplishes its main job as a transcription factor, the roles of the NF-kappaB system in immunity and inflammation, how NF-kappaB controls cell death, survival and metabolism, and how all of these functions go awry during disease development - something that we have learned both from studies of genetically altered mice and from studies of human genetic defects and pathology. Finally, this meeting will teach us how we might fix and cure these problems through the pharmacological targeting of the NF-kappaB system. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Ubiquitin Signaling, which will share a keynote address and three plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: NF-kappaB transcription factors are master regulators of immune and inflammatory responses which, when deregulated, are important causes of cancer, inflammatory diseases as well as diseases outside the immune system. The Keystone Symposia meeting on NF-kappaB Signaling and Biology: From Bench to Bedside will examine how we might fix and cure these problems through the pharmacological targeting of the NF-kappaB system.