Regenerative Tissue Engineering and Transplantation

再生组织工程与移植

• 批准号: 8256913
• 负责人: James Wavell Aiken
• 金额: $ 1.56万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256913
• 关键词: Address; Advanced Development; Affect; Basic Science; Biocompatible Materials; Biological; Biological Sciences; Bladder; Cells; Clinical Medicine; Collaborations; Colorado; Communities; Development; Disease; Engineering; Individual; Injury; Knowledge; Medicine; Methodology; Musculoskeletal; Nerve; Organ; Outcome; Participant; Procedures; Regenerative Medicine; Regulation; Request for Proposals; Research; Research Personnel; Scientist; Solid; Stem cells; Structure; Technology; Therapeutic; Tissue Engineering; Tissue Transplantation; Tissues; Training; Translational Research; Transplantation; Trauma; Vision; base; clinical application; clinical practice; experience; functional loss; injured; insight; meetings; novel; organ regeneration; reconstruction; regenerative; regenerative therapy; repaired; scaffold; stem; symposium; tissue regeneration; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Regenerative Tissue Engineering and Transplantation, organized by Rocky S. Tuan, Farshid Guilak and Anthony Atala, which will be held in Breckenridge, Colorado from April 1 - 6, 2012. Tissue engineering and regenerative medicine is a dynamic, translational research field that amalgamates life sciences, engineering, and clinical medicine for the purpose of restoring structure and function to diseased, damaged or injured tissues and organs. Current efforts focus on the application of stem and progenitor cells, bioactive factors and biomaterial scaffolds in transplantation procedures to affect regenerative therapies. Breakthroughs in bladder and tracheal reconstruction and highly promising approaches for solid organ regeneration as well as musculoskeletal and nerve repair have been achieved. Effective cell sourcing, optimal assembly and fabrication of tissue-derived and synthetic biomaterial scaffolds, and targeted regulation of therapeutic and immunomodulatory functions of stem cells represent some of the current challenges in this field. In this Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation, exciting technological and intellectual advances in the field will be synthesized by expert scientists, engineers, and clinicians to assess and expand the landscape in regenerative engineering and transplantation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting. More specifically, the pairing of these 2 meetings represents a highly unusual opportunity for crosstalk between the more applications-driven field of tissue engineering and regenerative medicine, and the very basic research being explored in the field of whole organ regeneration. PUBLIC HEALTH RELEVANCE: Structural and functional loss of tissues and organs through disease, injury, and trauma is a significant challenge in medicine. Development of advanced regenerative and transplantation technologies is of essential benefit to these affected individuals. The Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation will directly address challenges in this field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.

描述（由申请人提供）：本提案请求支持由Rocky S.图安、法希德·吉拉克和安东尼·阿塔拉，将于2012年4月1日至6日在科罗拉多州布雷肯里奇举行。组织工程和再生医学是一个动态的，转化的研究领域，融合了生命科学，工程学和临床医学，旨在恢复患病，受损或受伤组织和器官的结构和功能。目前的努力集中在干细胞和祖细胞，生物活性因子和生物材料支架在移植过程中的应用，以影响再生治疗。膀胱和气管重建的突破性进展以及实体器官再生以及肌肉骨骼和神经修复的非常有前途的方法已经实现。有效的细胞来源，组织衍生和合成生物材料支架的最佳组装和制造，以及干细胞的治疗和免疫调节功能的靶向调节代表了该领域当前的一些挑战。在这次关于再生组织工程和移植的Keystone研讨会上，该领域令人兴奋的技术和知识进步将由专家科学家，工程师和临床医生合成，以评估和扩大再生工程和移植的前景。同时举行的关于全器官再生机制的会议将大大加强跨学科互动的机会，该会议将与本次会议分享开幕式和闭幕式主旨演讲以及两次全体会议。更具体地说，这两个会议的配对代表了一个非常不寻常的机会，可以在组织工程和再生医学的应用驱动领域与整个器官再生领域正在探索的非常基础的研究之间进行交流。 公共卫生相关性：由于疾病、损伤和创伤导致的组织和器官的结构和功能丧失是医学中的重大挑战。先进的再生和移植技术的发展对这些受影响的人至关重要。再生组织工程和移植的Keystone研讨会会议将直接解决这一领域的挑战。同时举行的关于全器官再生机制的会议将大大加强跨学科互动的机会，该会议将与本次会议分享开幕式和闭幕式主旨演讲以及两次全体会议。