The Life of a Stem Cell: From Birth to Death

描述(申请人提供)：本提案请求支持将于2012年3月11日至16日在加利福尼亚州奥运谷举行的题为《干细胞的生命：从出生到死亡》的Keystone研讨会，该会议由玛格丽特·A·古德尔、露丝·莱曼和托马斯·A·兰多组织。干细胞研究已经证明了细胞分化程序的意外可塑性，并挑战了长期存在的细胞在发育过程中命运逐渐不可逆转的范式。干细胞生物学领域与基础生物学的许多领域相联系，包括发育生物学、组织生长和动态平衡、再生、癌症和衰老。与大多数关于干细胞的会议不同，Keystone研讨会的主题是干细胞的生命：从出生到死亡，会议的重点是有机体背景下的干细胞。干细胞系统涉及整个生物体的生命周期：配子发生和胚胎发生，建立组织类型；成熟，器官系统保持动态平衡；衰老，干细胞系统发生生理变化或因疾病而变化。选择发言者是为了广泛反映从各种模式生物、实验方法和器官系统中学到的经验教训。 与公共卫生相关：干细胞生物学是现代生物学中发展最快的领域之一。对干细胞生物学及其操作的更好理解为组织和器官的再生能力提供了新的见解，并为癌症和衰老等疾病的潜在细胞机制提供了新的理解。关于干细胞的生命：从出生到死亡的Keystone研讨会会议将寻求解决关于不同干细胞群体之间的主要差异以及它们各自的环境如何促成这些功能差异的知识差距。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled The Life of a Stem Cell: From Birth to Death, organized by Margaret A. Goodell, Ruth Lehmann and Thomas A. Rando, which will be held in Olympic Valley, California from March 11 - 16, 2012. Stem cell studies have demonstrated unexpected plasticity of cellular differentiation programs and challenged the long-standing paradigm of progressive irreversibility of cell fate during development. The field of stem cell biology interfaces with many areas of basic biology including developmental biology, tissue growth and homeostasis, regeneration, cancer and aging. Unlike most meetings on stem cells, the Keystone Symposia meeting on The Life of a Stem Cell: From Birth to Death focuses on stem cells within the context of the organism. Stem cell systems are discussed with respect to the life cycle of whole organisms: gametogenesis and embryogenesis, where tissue types are established; maturity, where organ systems are maintained in homeostasis; and aging, where stem cells systems change physiologically or because of disease. Speakers have been chosen to broadly reflect lessons learned from a variety of model organisms, experimental approaches and organ systems. PUBLIC HEALTH RELEVANCE: Stem cell biology is one of the most rapidly growing fields in modern biology. A better understanding of the biology of stem cells and their manipulation has generated new insight into the regenerative capacity of tissues and organs and has provided new understanding of the cellular mechanisms underlying diseases such as cancer and aging. The Keystone Symposia meeting on The Life of a Stem Cell: From Birth to Death will seek to address the gaps in knowledge regarding the major differences between different populations of stem cells and how their respective environments contribute to these functional differences.