Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology

2 型免疫：启动、维持、稳态和病理

• 批准号: 8399493
• 负责人: James Wavell Aiken
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399493
• 关键词: Address; Allergic; Area; Asthma; Biology; Childhood; Chronic; Chronic Disease; Chronic Obstructive Airway Disease; Collaborations; Developed Countries; Development; Discipline; Disease; Eczema; Endocrinologist; Epithelial; Faculty; Fertilization; Food Hypersensitivity; Fostering; Future; Goals; Health Care Costs; Helminths; Homeostasis; Human; Human Microbiome; Hypersensitivity; IgE; Immune; Immune response; Immune system; Immunity; Immunologist; Infection; Infiltration; Inflammatory; Intestines; Investigation; Knowledge; Link; Lymphoid Cell; Maintenance; Mentors; Metabolic Diseases; Metabolism; New Mexico; Organism; Outcome; Pathologic; Pathology; Population; Process; Reagent; Research; Research Personnel; Role; Scientist; Serum; Th2 Cells; Tissues; United States; design; economic cost; eosinophil; fitness; graduate student; human disease; insight; interdisciplinary collaboration; meetings; microbiome; novel; novel therapeutics; pressure; public health relevance; response; symposium

Description (as provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology, organized by Richard M. Locksley and Judith E. Allen. The meeting will be held in Santa Fe, New Mexico from January 10 - 15, 2013. Diseases associated with allergy and asthma are increasing in developed countries, with great consequences to health care costs. Often, these diseases reflect pathologic outcomes of type 2 immunity, and are characterized by infiltration of tissues with Th2 cells and eosinophils, by elevations in serum IgE, and by alterations in epithelial and mucosal biology. These responses did not evolve to cause allergies, and clues to the evolutionary pressure to maintain this type of immune response may exist in the response to intestinal helminths, which cause chronic infestations in all vertebrate species on earth. This meeting will bring together scientists from diverse disciplines to discuss new findings in type 2 immunity that suggest close associations of these responses with tissue homeostasis, mucosal microbiomes, and immune integrity that optimize overall fitness of the organism. The goals of this meeting are as follows: 1) to identify gaps in our understanding of type 2 immunity and facilitate future research advances in the field; 2) to promote the development of novel therapeutic strategies against diseases associated with type 2 immunity; and 3) to encourage cross-disciplinary collaborations and establish an on-going dialogue for future research. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Pathogenic Processes in Asthma and COPD, which will share a keynote address and two plenary sessions with this meeting.

描述（由申请人提供）：请求支持由Richard M.组织的题为2型免疫：启动、维持、稳态和病理学的Keystone研讨会会议。Locksley和Judith E.艾伦。会议将于2013年1月10日至15日在新墨西哥州圣达菲举行。在发达国家，与过敏和哮喘相关的疾病正在增加，这对医疗保健费用产生了巨大影响。通常，这些疾病反映了2型免疫的病理结果，其特征在于Th 2细胞和嗜酸性粒细胞浸润组织，血清IgE升高，上皮和粘膜生物学改变。这些反应并没有进化到引起过敏，维持这种类型的免疫反应的进化压力的线索可能存在于对肠道蠕虫的反应中，肠道蠕虫在地球上所有脊椎动物物种中引起慢性感染。本次会议将汇集来自不同学科的科学家，讨论2型免疫的新发现，这些发现表明这些反应与组织稳态，粘膜微生物组和免疫完整性密切相关，从而优化生物体的整体适应性。本次会议的目标如下：1）确定我们对2型免疫的理解的差距，并促进该领域未来的研究进展; 2）促进针对2型免疫相关疾病的新型治疗策略的开发; 3）鼓励跨学科合作，并为未来的研究建立持续的对话。跨学科互动的机会将显着提高了并发会议上的哮喘和慢性阻塞性肺病的致病过程，这将分享一个主旨演讲和两个全体会议与本次会议。