Malaria

描述（由申请人提供）：请求支持名为“疟疾”的 Keystone 研讨会，该会议由 Fidel P. Zavala、Andrew P. Waters、Kevin Marsh 和 Carolina V. Barillas-Mury 组织。会议将于2013年1月20日至25日在路易斯安那州新奥尔良举行。疟疾影响数亿人，每年导致近100万人死亡。控制和最终根除疟疾需要多学科协调一致的努力，通过疫苗和抗寄生虫药物来降低寄生虫的传染性，并防止传播到脊椎动物宿主。在本次会议中，我们将促进以下问题的讨论：1）对疟原虫感染的先天性和适应性免疫反应以及寄生虫如何干扰这些反应。我们还将讨论新佐剂的开发和抗疟疾疫苗策略。 2) 影响感染和耐药性发展的疟原虫细胞和群体生物学的基本方面。 3) 疟原虫传播，包括配子细胞发生和蚊媒中的疟原虫生物学。这包括寄生虫-蚊子相互作用的细胞和分子方面、实地研究、功能基因组学和潜在控制策略的开发。 4) 流行地区的严重疟疾、我们对人类和动物模型疾病生理病理学理解的最新进展，以及基于基因组的策略来识别严重疾病易感性的生物标志物。由于基础和转化疟疾研究明显是多学科的，2013 年 Keystone 疟疾研讨会将汇集从基础分子研究到群体生物学等学科领域的研究人员。这次会议将促进思想交流，以加深我们对疟疾的了解并制定新的控制措施。此外，我们预计这次会议将使我们能够确定该领域面临的下一代挑战并确定优先顺序。

Description (as provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Malaria, organized by Fidel P. Zavala, Andrew P. Waters, Kevin Marsh and Carolina V. Barillas-Mury. The meeting will be held in New Orleans, Louisiana from January 20 - 25, 2013. Malaria affects hundreds of millions of people and causes nearly 1 million deaths per year. The control and eventual eradication of malaria will require a concerted, multidisciplinary effort to decrease parasite infectivity through vaccines and anti-parasitic drugs, and by preventing transmission to the vertebrate host. In this meeting we will promote discussion of: 1) Innate and adaptive immune responses to Plasmodium infection and how the parasite interferes with these responses. We will also discuss the development of new adjuvants and anti-malaria vaccine strategies. 2) Basic aspects of Plasmodium cellular and population biology that affect infection and the development of drug resistance. 3) Plasmodium transmission, including gametocytogenesis and Plasmodium biology in the mosquito vector. This includes cellular and molecular aspects of parasite-mosquito interactions, field studies, functional genomics and the development of potential control strategies. 4) Severe malaria in endemic areas, recent advances in our understanding of the physiopathology of disease in humans and in animal models, and genome-based strategies to identify biomarkers of susceptibility to severe disease. Since basic and translational malaria research is eminently multidisciplinary, the 2013 Keystone Symposia meeting on Malaria will bring together researchers working in disciplines ranging from basic molecular studies to population biology. This encounter will promote the exchange of ideas to both deepen our understanding of malaria and to develop novel control measures. Furthermore, we anticipate that this meeting will enable us to identify and prioritize the next generation of challenges faced by the field.