Noncoding RNAs in Development and Cancer

非编码 RNA 在发育和癌症中的作用

• 批准号: 8391064
• 负责人: James Wavell Aiken
• 金额: $ 0.2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8391064
• 关键词: Affect; Biochemical; Biology; British Columbia; Caenorhabditis elegans; Canada; Cancer Biology; Cell Nucleus; Cells; Chromatin; Code; Collaborations; Cues; Data; Development; Developmental Biology; Disease; Epigenetic Process; Explosion; Faculty; Fostering; Gene Expression; Gene Expression Regulation; Genes; Genetic Transcription; Genome; Germ Cells; Goals; Health; Investigation; Knowledge; Malignant Neoplasms; Mentorship; Messenger RNA; Methodology; MicroRNAs; Molecular; Outcome; Participant; Pathway interactions; Phenotype; Physiological; Physiology; Play; Postdoctoral Fellow; Process; Proteins; RNA; RNA Processing; Recurrence; Regulator Genes; Research; Research Personnel; Role; Senior Scientist; Small RNA; Students; Therapeutic; Time; Training; Transcript; Translations; Untranslated RNA; Work; cell behavior; clinical practice; deep sequencing; man; meetings; neoplastic cell; novel; novel therapeutics; public health relevance; scaffold; symposium; tumor

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Noncoding RNAs in Development and Cancer, organized by Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang, which will be held in Vancouver, British Columbia, Canada from January 20 - 25, 2013. A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of 1) illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal- level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches, and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.

描述（由申请人提供）：请求支持由约书亚T. Mendell，菲利普A.放大图片作者：Judy Lieberman和霍华德Y. Chang，将于2013年1月20日至25日在加拿大不列颠哥伦比亚省的温哥华举行。癌症生物学中的一个反复出现的原则是在发育过程中起作用的途径的共同选择，以促进异常的肿瘤细胞行为。这一原则显然适用于非编码RNA在癌症中的作用。修饰肿瘤表型的非编码RNA的例子包括microRNA（miRNA）let-7，它是C. elegans和miR-17-92簇，其在哺乳动物发育期间进行必要的调节功能。然而，我们目前只有一个基本的了解如何不同类别的非编码RNA的功能在生理和病理生理状态。本次会议将汇集专家专注于非编码RNA在发育和癌症中的作用，其广泛目标是：1）阐明由miRNA和长非编码RNA控制的发育和癌症途径之间的新联系; 2）揭示发育和癌症途径影响非编码RNA加工和活性的新机制; 3）揭示miRNAs和长链非编码RNA在这些通路中发挥作用的分子机制;以及4）强调我们对非编码RNA的理解-受调节的途径可以应用于癌症和可能的其他疾病的新治疗策略的开发。为了实现这些目标，本次会议将汇集来自不同领域的专家，从生物体水平的发育和癌症生物学到RNA功能的生物化学和分子研究，分享他们的最新数据和想法。预计参与者提出的不同观点，方法和结果将促进新的调查和合作，这对于剖析非编码RNA在健康和疾病中的无数功能至关重要。