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Molecular Aspects of Tsetse and Trypanosome Transmission

采采蝇和锥虫传播的分子方面

基本信息

批准号：
8306932
负责人：
Serap AKSOY
金额：
$ 47.25万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-12-15 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8306932
关键词：
Africa South of the Sahara African African Trypanosomiasis Animals Antiparasitic Agents Bacteria Binding Biochemical Biology Blood Community Participation Competence Development Disease Drosophila genus Engineering Exhibits Exposure to Female Fertility Foundations Gene Expression Genetic Goals Grant Homeostasis Human Immune Immune response Immune system Immunity Infection Inherited Insecta Investigation Knowledge Mediating Microbe Midgut Modification Molecular Nature Nutrient Organism Parasite resistance Parasites Peptidoglycan Pharmaceutical Preparations Population Prevention Process Proteins Reaction Recombinants Refractory Research Resistance Role Staging Sterility System Systems Development Technology Testing Therapeutic Transgenic Organisms Trypanosoma Tsetse Flies Vaccines War Wolbachia base dietary restriction disorder control feeding fitness fly invertebrate host killings male microbial novel novel strategies pathogen peptidoglycan recognition protein prevent programs receptor reproductive resistance mechanism response transmission process vector vector control

项目摘要

Project Summary This application is on preventing Human African trypanosomiasis (HAT), which kills thousands of people each year in sub-Saharan Africa. The disease is caused by African trypanosomes transmitted by the tsetse fly. No mammalian vaccines, or effective and affordable therapeutic drugs exist. In contrast, reduction of tsetse populations can be highly efficacious for disease control although traditional strategies have been difficult to sustain because they require extensive community participation in deprived, remote and war-torn regions typically afflicted by this disease. Recombinant technologies now promise the development of novel approaches, including modification of the vector competence of the fly. This application proposes to investigate the fundamental aspects of tsetse immune biology as it relates to the pathogenic trypanosomes it transmits, and the obligate mutualist symbionts it relies on for fecundity. The application has two goals: (1) to investigate the molecular basis of tsetse's refractoriness to trypanosome transmission with a focus on the role of pathogen recognition molecules, and (2) to understand the responses and the evolutionary dynamics of tsetse's immune reactions that regulate symbiotic homeostasis and vector competence. Identification of host immune proteins that result in parasite resistance can strengthen efforts that can reduce tsetse's vector competence via genetic modification. Understanding the mechanism of tolerance to symbiotic fauna may result in novel vector control strategies that aim to reduce tsetse's fecundity.

项目总结