ISOLATION OF A NEW HIV-2 GROUP IN THE US

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心赠款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的总体目标是评估塞拉利昂一种新的HIV-2 F组毒株的流行情况。 在美国有一个艾滋病毒2-F病例，据记录，该病例起源于塞拉利昂地区，将对该病例进行调查。 HIV-2-F疾病在人群中的流行病学和发病机制尚不清楚，但现有数据表明，它可能起源于在塞拉利昂发现的SIV毒株。 由于上次调查是在18年前进行的，目前缺乏关于艾滋病毒-2在人口中流行情况的数据，而艾滋病毒-2-F可能代表一种新出现的艾滋病。 为此，我们将对塞拉利昂北方的人口进行艾滋病毒2-F感染流行率筛查。 我们将使用已在该地区验证的抗体检测。 我们还将使用基于PCR的检测来筛选由于抗体滴度下降而可能遗漏的样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this project is to assess the prevalence of a novel strain of HIV-2 group F in Sierra Leone. There has been one case of HIV-2-F in the United States documented that originated in the area of Sierra Leone that will be surveyed. The epidemiology and pathogenesis of HIV-2-F disease in human populations is unknown although available data suggest that it may have originated from a strain of SIV found in sooty mangabeys in Sierra Leone. Data on the prevalence of HIV-2 in human populations are presently lacking as the last survey was made 18 years ago and HIV-2-F may represent an emerging AIDS. To this end we will screen the human population in Northern Sierra Leone for prevalence of HIV-2-F infections. We will use antibody assays that have already been validated in this region. We will also use PCR based testing to screen samples that may be missed due to waning antibody titers.