ISOLATION OF A NEW HIV-2 GROUP IN THE US

美国隔离新的 HIV-2 群体

• 批准号: 8358116
• 负责人: Preston A Marx
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358116
• 关键词: Acquired Immunodeficiency Syndrome; Antibodies; Area; Biological Assay; Cercocebus atys; Data; Disease; Epidemiology; Funding; Grant; HIV-2; Human; Infection; National Center for Research Resources; Pathogenesis; Population; Prevalence; Primates; Principal Investigator; Research; Research Infrastructure; Resources; SIV; Sampling; Sierra Leone; Source; Surveys; Testing; United States; United States National Institutes of Health; base; cost; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this project is to assess the prevalence of a novel strain of HIV-2 group F in Sierra Leone. There has been one case of HIV-2-F in the United States documented that originated in the area of Sierra Leone that will be surveyed. The epidemiology and pathogenesis of HIV-2-F disease in human populations is unknown although available data suggest that it may have originated from a strain of SIV found in sooty mangabeys in Sierra Leone. Data on the prevalence of HIV-2 in human populations are presently lacking as the last survey was made 18 years ago and HIV-2-F may represent an emerging AIDS. To this end we will screen the human population in Northern Sierra Leone for prevalence of HIV-2-F infections. We will use antibody assays that have already been validated in this region. We will also use PCR based testing to screen samples that may be missed due to waning antibody titers.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目的总体目的是评估塞拉利昂的HIV-2组F菌株的普遍性。 美国已有一例HIV-2-F案件，该案件起源于塞拉利昂地区，将进行调查。 人群中HIV-2-F疾病的流行病学和发病机理尚不清楚，尽管可用的数据表明，它可能起源于塞拉利昂的Sooty Mangabeys中的SIV菌株。 目前缺乏有关人群中HIV-2患病率的数据，因为上一项调查是18年前进行的，而HIV-2-F可能代表了新兴的艾滋病。 为此，我们将筛选塞拉利昂北部的人口，以了解HIV-2-F感染的流行。 我们将使用在该区域已验证的抗体测定。 我们还将使用基于PCR的测试对屏幕样品，这些样品由于抗体滴度的减弱而丢失。