Neuroendocrine Control of Paternal Care in the Common Marmoset

普通狨猴父亲照顾的神经内分泌控制

• 批准号: 7586562
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 18.48万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-05 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586562
• 关键词: Adult; Anterior; Anterior Pituitary Gland; Behavior; Behavioral; Birth; Brain; Callithrix; Callithrix jacchus jacchus; Caring; Child Development; Communication; Cues; Development; Disease; Dopamine; Dose; Estradiol; Event; Exhibits; Fathers; Female; Foundations; Health; Hormonal; Hormonal Change; Human; Hypothalamic structure; In Vitro; Infant; Infant Care; Mammals; Maternal Behavior; Monitor; Neurosecretory Systems; Outcome; Oxytocin; Parenting behavior; Partner in relationship; Paternal Behavior; Pathway interactions; Peptides; Peripheral; Pituitary Gland; Pituitary Hormones; Posterior Pituitary Gland; Pregnancy; Primates; Production; Prolactin; Rodent; Role; Sampling; Sheep; Steroids; Stimulus; Study models; Testing; Testosterone; Ursidae Family; Vasopressins; abuse neglect; experience; family structure; in vitro testing; in vivo; male; method development; novel; offspring; psychosocial; public health relevance; relating to nervous system; reproductive; research study; response; social organization; steroid hormone; therapy development

DESCRIPTION (provided by applicant): The use of the exploratory/development mechanism was chosen to allow for the development of methods to examine the hormonal pathway for priming paternal care behaviors in biparental males. The common marmoset, Callithrix jacchus, is the ideal model for studying hormonal activation of male parental care due to their active participation in infant care from the first day of birth. Fathers are highly responsive to infant cues, but show between male variability as do human fathers. Parentally naive males are much less responsive to infant cues than experienced males, suggesting there is an experience and hormonal influence on paternal behavior. Specific Aim 1 will test paternally experienced adult male marmosets for their infant responsiveness to an infant or control stimulus by steroid treatment with either estradiol or testosterone or vehicle. We will examine changes in prolactin, oxytocin, vasopressin and dopamine with steroid stimulation in both central and peripheral samples. Specific Aim 2 will examine the communication between the anterior and posterior pituitary through culturing both intact and separated pituitaries before and after steroid challenges. Changes in levels of pituitary hormones will be compared to in vivo changes found in Specific Aim 1. Specific Aim 3 will test paternally naive males for their infant responsiveness by steroid treatment, as in Specific Aim 1 and for their pituitary responses as in Specific Aim 2. Inexperienced male's behavioral and hormonal responses will be compared to experienced males and pituitary responses to steroid treatment will be compared with the experienced males. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. Poor parenting results in a number of pyschosocial disorders, such as neglect and abuse, which confound human health. Understanding the mechanisms of paternal care in a bi-parental species will lay the foundation for development of treatments to create positive parenting. PUBLIC HEALTH RELEVANCE: This project seeks to understand the factors underlying quality paternal care in males. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Fathers can contribute significantly to the positive outcome of infant and child development.

描述（由申请人提供）：选择了探索/发展机制的使用，以允许开发方法来检查双方男性启动父亲护理行为的荷尔蒙途径。共同的果果会Callithrix Jacchus是研究男性父母护理激素的理想模型，因为它们从出生的第一天就积极参与了婴儿护理。父亲对婴儿提示的反应高度敏感，但在男性的变异性之间表现出来。与经验丰富的男性相比，父母天真的男性对婴儿提示的反应要小得多，这表明对父亲行为有经验和荷尔蒙影响。特定的目标1将通过用雌二醇或睾丸激素或媒介物治疗类固醇治疗，测试经验丰富的成年男性雄性摩尔果会对婴儿对婴儿或对照刺激的反应。我们将检查中央和外围样品中催乳素，催产素，加压素和多巴胺的变化。特定的目标2将通过在类固醇挑战之前和之后通过完整和分离的垂体培养前垂体和后垂体之间的交流。垂体激素水平的变化将与特定目的1中的体内变化进行比较。特定目标3将通过类固醇治疗来测试其婴儿的婴儿反应能力，如特定的目标1，以及在特定目标2中的垂体反应2。在经验不足的男性行为和荷尔蒙反应中，将与经验丰富的男性治疗与经验丰富的男性相比，将其与经验丰富的男性相提并论，以便与ut依uite症相比。摩尔果是其社会组织/家庭结构与人类相似的少数哺乳动物物种之一。育儿差会导致许多杂交疾病，例如忽视和虐待，使人类健康混淆。了解双亲物种中父亲护理的机制将为建立积极的育儿发展奠定基础。公共卫生相关性：该项目旨在了解男性质量质量护理的基本因素。由于育儿或父母的缺席，有许多使人健康混淆的社会心理障碍。父亲可以为婴儿和儿童成长的积极结果做出重大贡献。