MECHANISM OF ACTION OF NOVEL HORMONE THERAPIES IN ADULT MALE RHESUS MONKEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：提高对新型抗雄激素药物应用于男性前列腺癌治疗的认识。 本研究将检测新型抗雄激素药物对成年雄性恒河猴体内性激素的影响。内分泌激发试验和液-质联用激素测定正被应用于在与人类密切相关的动物模型中确定药物作用机制。 这项研究使用了WNPRC动物服务和病理服务。 出版物： 没有。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To improve our understanding of novel anti-androgen drugs for application to the treatment of prostate cancer in men. This study will examine the sex hormone changes induced in adult male rhesus monkeys by novel anti-androgen drugs. Endocrine challenge tests and liquid chromatography-mass spectrometry hormone determination are being applied to identify mechanism of drug action in an animal model closely related to the human. This research uses WNPRC Animal Services and Pathology Services. PUBLICATIONS: None.