RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

基本信息

  • 批准号:
    8358197
  • 负责人:
  • 金额:
    $ 4.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin (5-HT) neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We developed a model system with female common marmosets to demonstrate that flibanserin stimulation of 5-HT1A (agonist) and 5-HT2A (antagonist) postsynaptic receptors increases male attention to female genital area without altering female sexual behavior, while chronic stimulation of pre- and post-synpatic 5-HT1A receptors by 8-OH-DPAT diminishes female sexual receptivity. Flibanserin also encourages a positive dynamic (allogrooming) between treated females and their male pairmates, in contrast to the negative dynamic engaged by 8-OH-DPAT (aggression, sexual rejection of the male). Postsynaptic action of flibanserin may be preferentially focused on the prefrontal cortex. As there were no observed behavioral differences between females receiving estradiol or no hormone, flibanserin may counteract low sexual desire in women, before or after menopause, by supporting positive interactions with their partner. This research used WNPRC Assay Services and Animal Services. Publications are pending.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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DAVID H ABBOTT其他文献

DAVID H ABBOTT的其他文献

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{{ truncateString('DAVID H ABBOTT', 18)}}的其他基金

POLYCYSTIC OVARY SYNDROME (PCOS) AND FETAL, NEONATAL AND ADULT BIOMARKERS
多囊卵巢综合症 (PCOS) 和胎儿、新生儿和成人生物标志物
  • 批准号:
    8358196
  • 财政年份:
    2011
  • 资助金额:
    $ 4.61万
  • 项目类别:
MECHANISM OF ACTION OF NOVEL HORMONE THERAPIES IN ADULT MALE RHESUS MONKEYS
新型激素疗法对成年雄性恒河猴的作用机制
  • 批准号:
    8358249
  • 财政年份:
    2011
  • 资助金额:
    $ 4.61万
  • 项目类别:
NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES
非人类灵长类动物自然发生的多囊卵巢综合症 (PCOS)
  • 批准号:
    8358239
  • 财政年份:
    2011
  • 资助金额:
    $ 4.61万
  • 项目类别:
RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR
恢复女性性行为的正常频率和持续时间
  • 批准号:
    8173073
  • 财政年份:
    2010
  • 资助金额:
    $ 4.61万
  • 项目类别:
NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES
非人类灵长类动物自然发生的多囊卵巢综合症 (PCOS)
  • 批准号:
    8173165
  • 财政年份:
    2010
  • 资助金额:
    $ 4.61万
  • 项目类别:
EFFECTIVE DETECTION OF PCOS IN OLD WORLD MONKEYS
有效检测旧世界猴子中的多囊卵巢综合症
  • 批准号:
    8172467
  • 财政年份:
    2010
  • 资助金额:
    $ 4.61万
  • 项目类别:
POLYCYSTIC OVARY SYNDROME (PCOS) AND FETAL, NEONATAL AND ADULT BIOMARKERS
多囊卵巢综合症 (PCOS) 和胎儿、新生儿和成人生物标志物
  • 批准号:
    8173071
  • 财政年份:
    2010
  • 资助金额:
    $ 4.61万
  • 项目类别:
POLYCYSTIC OVARY SYNDROME AND FETAL AND NEONATAL BIOMARKERS
多囊卵巢综合症以及胎儿和新生儿生物标志物
  • 批准号:
    7958738
  • 财政年份:
    2009
  • 资助金额:
    $ 4.61万
  • 项目类别:
RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR
恢复女性性行为的正常频率和持续时间
  • 批准号:
    7958744
  • 财政年份:
    2009
  • 资助金额:
    $ 4.61万
  • 项目类别:
RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR
恢复女性性行为的正常频率和持续时间
  • 批准号:
    7716416
  • 财政年份:
    2008
  • 资助金额:
    $ 4.61万
  • 项目类别:

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