EFFECTIVE DETECTION OF PCOS IN OLD WORLD MONKEYS

有效检测旧世界猴子中的多囊卵巢综合症

• 批准号: 8172467
• 负责人: DAVID H ABBOTT
• 金额: $ 2.19万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172467
• 关键词: Adult; Biological Assay; Cardiovascular Diseases; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Endometrial Carcinoma; Etiology; Female; Funding; Grant; Human; Infertility; Institution; Intervention; Metabolic Diseases; Modeling; Nature; Non-Insulin-Dependent Diabetes Mellitus; Ovarian; Phenotype; Pilot Projects; Polycystic Ovary Syndrome; Population; Primates; Research; Research Personnel; Resources; Risk; Sampling; Services; Source; Syndrome; Ultrasonography; United States National Institutes of Health; Wisconsin; Woman; falls; lifetime risk; nonhuman primate; novel; prevent; reproductive; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a translational multi-center project to initiate novel studies into the pathophysiological origins of a highly prevalent reproductive and metabolic disorder in women, namely polycystic ovary syndrome (PCOS). This hyperandrogenic syndrome increases a woman's lifetime risk of type 2 diabetes, cardiovascular disease, endometrial cancer and infertility. Our focus on PCOS stems from the highly pervasive, but heterogeneous nature of the disease, and our incomplete understanding of its etiology in women. We now need a naturally-occurring phenotype in a nonhuman primate model as well as an ability to target children at risk of PCOS to develop novel clinical interventions to prevent or diminish the adult PCOS phenotype. In this pilot project begun in late Fall 2009, we propose to establish the efficacy of both nonhuman primate and human approaches with a consortium of multiple Primate Centers and the Wisconsin CTSA. Our targeted use of appropriate nonhuman primate populations and expertise at three Primate Centers minimizes redundancies in resources available nationally and our utilization of Assay Services within the WCTSA demonstrates our sharing of a single core resource. Thus far, the Yerkes Center has collected samples and performed ovarian ultrasounds on some 20 of the 100 females needed. All samples will be sent to Dr Abbott at the WNPRC for analyses.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一个转化多中心项目，旨在启动对女性中高度流行的生殖和代谢疾病（即多囊卵巢综合征（PCOS））的病理生理起源的新研究。这种高雄激素综合征会增加女性一生中患2型糖尿病、心血管疾病、子宫内膜癌和不孕症的风险。 我们对PCOS的关注源于这种疾病的高度普遍性，但异质性，以及我们对其女性病因的不完全理解。我们现在需要在非人灵长类动物模型中自然发生的表型，以及针对有PCOS风险的儿童的能力，以开发新的临床干预措施来预防或减少成人PCOS表型。 在2009年秋末开始的这个试点项目中，我们建议与多个灵长类动物中心和威斯康星州CTSA的联盟建立非人灵长类动物和人类方法的有效性。 我们在三个灵长类动物中心有针对性地使用适当的非人灵长类动物种群和专业知识，最大限度地减少了全国可用资源的冗余，我们在WCTSA内使用分析服务，表明我们共享单一核心资源。 到目前为止，耶基斯中心已经收集了样本，并对所需的100名女性中的20名进行了卵巢超声检查。 所有样本将被送往WNPRC的Abbott博士进行分析。