NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：了解美国3个灵长类中心非人灵长类人群多囊卵巢综合征(PCOS)的发病率和表型特征。 这一试点项目将确定两种猕猴的表型特征和自然发生的多囊卵巢综合征的发生率，这些猕猴通常被用作生殖和代谢障碍的生物医学研究模型。该项目将提供单个性状的遗传力指标，以及两个猕猴物种中每个性状的流行程度，并将为更深入的研究提供基础，以探讨猴子多囊卵巢综合征的病因。该项目还将指出新生恒河猴婴儿头发中的雄激素含量，头发是先前接触雄激素的储存库，是否可以表明哪些胎儿有较高的胎儿暴露。用液相色谱-质谱法测定的新生儿头发样本的初步结果表明，新生雄性猕猴的毛发比新生的雌性猕猴的头发含有更多的雄激素，这与已知的雄性胎儿接触到更高水平的雄激素的情况是一致的。新生儿血液样本没有显示出这种性别差异。 本研究使用了WNPRC化验服务、CPI和动物服务。 出版物： 没有。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the incidence and phenotypic traits of polycystic ovary syndrome (PCOS) in nonhuman primate populations at three US Primate Centers. This pilot project will determine the phenotypic traits and incidence of naturally occurring PCOS in two species of macaque monkeys commonly used as biomedical research models for reproductive and metabolic disorders. The project will provide an indication of heritability of individual traits, the prevalence of each trait within each of the two macaque monkey species, and will provide the basis for a more in-depth study to examine causation of the PCOS disorder in monkeys. The project will also indicate whether androgen content of newborn rhesus monkey infant hair, hair is a repository of prior exposure to androgen, can indicate which fetuses had higher fetal exposure. Preliminary results from newborn hair samples determined by liquid chromatography-mass spectrometry indicate that newborn male rhesus monkey hair contains more androgen than newborn female, consistent with known exposure of fetal males to higher levels of androgen. Newborn blood samples did not show this sex difference. This research uses WNPRC Assay Services, CPI and Animal Services. PUBLICATIONS: None.