NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES

非人类灵长类动物自然发生的多囊卵巢综合症 (PCOS)

• 批准号: 8358239
• 负责人: DAVID H ABBOTT
• 金额: $ 14.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358239
• 关键词: Androgens; Animals; Biological Assay; Biomedical Research; Blood specimen; Disease; Etiology; Exposure to; Female; Fetus; Funding; Grant; Hair; Heritability; Incidence; Individual; Infant; Macaca; Macaca mulatta; Metabolic Diseases; Modeling; Monkeys; National Center for Research Resources; Newborn Infant; Perinatal Exposure; Pilot Projects; Polycystic Ovary Syndrome; Population; Prevalence; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Services; Sex Characteristics; Source; United States National Institutes of Health; Wisconsin; base; cost; liquid chromatography mass spectrometry; male; nonhuman primate; repository; reproductive; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the incidence and phenotypic traits of polycystic ovary syndrome (PCOS) in nonhuman primate populations at three US Primate Centers. This pilot project will determine the phenotypic traits and incidence of naturally occurring PCOS in two species of macaque monkeys commonly used as biomedical research models for reproductive and metabolic disorders. The project will provide an indication of heritability of individual traits, the prevalence of each trait within each of the two macaque monkey species, and will provide the basis for a more in-depth study to examine causation of the PCOS disorder in monkeys. The project will also indicate whether androgen content of newborn rhesus monkey infant hair, hair is a repository of prior exposure to androgen, can indicate which fetuses had higher fetal exposure. Preliminary results from newborn hair samples determined by liquid chromatography-mass spectrometry indicate that newborn male rhesus monkey hair contains more androgen than newborn female, consistent with known exposure of fetal males to higher levels of androgen. Newborn blood samples did not show this sex difference. This research uses WNPRC Assay Services, CPI and Animal Services. PUBLICATIONS: None.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：确定美国三个灵长类动物中心非人灵长类动物群体中多囊卵巢综合征（PCOS）的发病率和表型特征。 该试点项目将确定两种猕猴中自然发生的PCOS的表型特征和发病率，这两种猕猴通常用作生殖和代谢疾病的生物医学研究模型。该项目将提供个体特征遗传性的指标，两种猕猴物种中每种特征的患病率，并将为更深入的研究提供基础，以检查猴子PCOS疾病的病因。该项目还将表明新生恒河猴幼猴毛发的雄激素含量，毛发是否是雄激素的既往暴露的储存库，可以表明哪些胎仔的暴露量较高。通过液相色谱-质谱法测定的新生儿毛发样品的初步结果表明，新生雄性恒河猴毛发比新生雌性含有更多的雄激素，这与已知的雄性胎儿暴露于更高水平的雄激素相一致。新生儿血液样本没有显示出这种性别差异。 本研究使用WNPRC Assay Services、CPI和Animal Services。 出版物： 没有。