NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 目的：确定美国三个灵长类动物中心非人灵长类动物群体中多囊卵巢综合征（PCOS）的发病率和表型特征。 该试点项目将确定两种猕猴中自然发生的PCOS的表型特征和发病率，这两种猕猴通常用作生殖和代谢疾病的生物医学研究模型。该项目将提供个体特征遗传性的指标，两种猕猴物种中每种特征的患病率，并将为更深入的研究提供基础，以检查猴子PCOS疾病的病因。 这项研究依赖于WNPRC分析服务，CPI和动物服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the incidence and phenotypic traits of polycystic ovary syndrome (PCOS) in nonhuman primate populations at three US Primate Centers. This pilot project will determine the phenotypic traits and incidence of naturally occurring PCOS in two species of macaque monkeys commonly used as biomedical research models for reproductive and metabolic disorders. The project will provide an indication of heritability of individual traits, the prevalence of each trait within each of the two macaque monkey species, and will provide the basis for a more in-depth study to examine causation of the PCOS disorder in monkeys. This research relies on WNPRC Assay Services, CPI and Animal Services.