NATURALLY-OCCURRING POLYCYSTIC OVARY SYNDROME (PCOS) IN NONHUMAN PRIMATES

非人类灵长类动物自然发生的多囊卵巢综合症 (PCOS)

• 批准号: 8173165
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173165
• 关键词: Animals; Biological Assay; Biomedical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Etiology; Funding; Grant; Heritability; Incidence; Individual; Institution; Macaca; Metabolic Diseases; Modeling; Monkeys; Pilot Projects; Polycystic Ovary Syndrome; Population; Prevalence; Primates; Research; Research Personnel; Resources; Services; Source; United States National Institutes of Health; base; nonhuman primate; reproductive; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the incidence and phenotypic traits of polycystic ovary syndrome (PCOS) in nonhuman primate populations at three US Primate Centers. This pilot project will determine the phenotypic traits and incidence of naturally occurring PCOS in two species of macaque monkeys commonly used as biomedical research models for reproductive and metabolic disorders. The project will provide an indication of heritability of individual traits, the prevalence of each trait within each of the two macaque monkey species, and will provide the basis for a more in-depth study to examine causation of the PCOS disorder in monkeys. This research relies on WNPRC Assay Services, CPI and Animal Services.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：了解美国3个灵长类中心非人灵长类人群多囊卵巢综合征(PCOS)的发病率和表型特征。 这一试点项目将确定两种猕猴的表型特征和自然发生的多囊卵巢综合征的发生率，这些猕猴通常被用作生殖和代谢障碍的生物医学研究模型。该项目将提供单个性状的遗传力指标，以及两个猕猴物种中每个性状的流行程度，并将为更深入的研究提供基础，以探讨猴子多囊卵巢综合征的病因。 这项研究依赖于WNPRC化验服务、CPI和动物服务。