RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

• 批准号: 8173073
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173073
• 关键词: Affect; Animals; Behavioral; Biological Assay; Biological Models; Brain imaging; Callithrix; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Estrogens; Female; Frequencies; Funding; Grant; Grooming; Hormonal; Human; Institution; Intervention; Mammals; Neurons; Outcome; Pharmaceutical Preparations; Pharmacotherapy; Positron-Emission Tomography; Progestins; Property; Publications; Research; Research Personnel; Resources; Safety; Serotonin; Serotonin Agents; Serotonin Receptor Binding; Services; Sex Behavior; Sexual Dysfunction; Social Interaction; Source; System; United States National Institutes of Health; Woman; analog; flibanserin; improved; male; neuromechanism; nonhuman primate; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to demonstrate that a serotonin analogue, 8-hydroxyDPAT, diminishes female acceptance of male sexual advances, while another, flibanserin, does not. Flibanserin also enhances positive social interactions between male-female pairs, including grooming. Non-invasive PET brain imaging suggests specific changes in female neural activity associated with the different behavioral outcomes for each serotonin drug. The different serotonin receptor binding properties of each drug are starting to provide clues as to neural mechanisms of action and theraputic application. Publications are pending. This research used WNPRC Assay Services and Animal Services.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：提高对绒猴雌猴性反应调节的神经机制的认识，为临床干预女性性功能减退提供依据。 据估计，性功能障碍影响了43%的女性。目前还没有批准的药物治疗这种疾病。对雌激素和孕激素激素治疗的安全性担忧促使人们寻求非甾体药物治疗。5-羟色胺神经元系统参与调节一系列雌性哺乳动物的性行为，包括人类和非人类灵长类动物，但所涉及的机制还不清楚。我们已经开发了一个模型系统与女性普通绒猴证明，血清素类似物，8-羟基DPAT，减少女性接受男性的性进步，而另一个，氟班色林，没有。Flibanserin还可以增强男女之间的积极社会互动，包括梳理。非侵入性PET脑成像表明女性神经活动的特定变化与每种5-羟色胺药物的不同行为结果相关。每种药物的不同5-羟色胺受体结合特性开始为神经作用机制和治疗应用提供线索。出版物待定。 本研究使用WNPRC Assay Services和Animal Services。