RESTORING NORMAL FREQUENCY AND DURATION OF FEMALE SEXUAL BEHAVIOR

恢复女性性行为的正常频率和持续时间

• 批准号: 8173073
• 负责人: DAVID H ABBOTT
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173073
• 关键词: Affect; Animals; Behavioral; Biological Assay; Biological Models; Brain imaging; Callithrix; Callithrix jacchus jacchus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Estrogens; Female; Frequencies; Funding; Grant; Grooming; Hormonal; Human; Institution; Intervention; Mammals; Neurons; Outcome; Pharmaceutical Preparations; Pharmacotherapy; Positron-Emission Tomography; Progestins; Property; Publications; Research; Research Personnel; Resources; Safety; Serotonin; Serotonin Agents; Serotonin Receptor Binding; Services; Sex Behavior; Sexual Dysfunction; Social Interaction; Source; System; United States National Institutes of Health; Woman; analog; flibanserin; improved; male; neuromechanism; nonhuman primate; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To improve our understanding of serotonin-related neural mechanisms regulating female sexual response in marmosets in order to develop more appropriate clinical intervention for sexual hypofunction in women. Sexual dysfunction affects an estimated 43% of women. Currently there are no approved drug therapies for this disorder. Safety concerns about hormonal treatment with estrogens and progestogens motivates the search for non-steroidal pharmoacotherapy. The serotonin neuronal system has been implicated in regulating sexual behavior in a range of female mammals, including humans and nonhuman primates, but the mechanisms involved are not well understood. We have developed a model system with female common marmosets to demonstrate that a serotonin analogue, 8-hydroxyDPAT, diminishes female acceptance of male sexual advances, while another, flibanserin, does not. Flibanserin also enhances positive social interactions between male-female pairs, including grooming. Non-invasive PET brain imaging suggests specific changes in female neural activity associated with the different behavioral outcomes for each serotonin drug. The different serotonin receptor binding properties of each drug are starting to provide clues as to neural mechanisms of action and theraputic application. Publications are pending. This research used WNPRC Assay Services and Animal Services.

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