Research Core

项目总结(见说明)： 由于有效的抗逆转录病毒治疗，艾滋病毒感染者现在通常能活到60岁和70岁。然而，感染艾滋病毒的老年人，即那些50岁及以上的人，过早地经历了许多70岁以上非感染者常见的慢性疾病，如认知能力下降、痴呆、身体虚弱和其他与老龄化有关的并存。 新出现的数据表明，少数群体受到这些过早的慢性病的影响不成比例，但很少有研究来描述和治疗这一人群中的这些慢性病。要消除老年艾滋病毒携带者的种族差异，就需要对艾滋病毒感染对少数群体中与衰老有关的共病的影响有新的认识。可以用来检查健康方面的种族差异的临床数据和来自感染艾滋病毒的老年少数民族的生物标本的可用来源相对较少。为了填补这一空白并解决迅速增长的公共卫生问题，拉什CEDHA研究核心将招募和招募一个独特的老年少数族裔和非少数族裔携带和不携带艾滋病毒的人队列，以提供纵向临床数据和生物标本来源。这些数据将被存储、编目，并通过储存库提供给当地和国家研究人员，以支持关注艾滋病毒和老龄化交叉的高质量、尖端临床和基础科学研究。此外，这些数据将与从非裔美国人和高加索背景的老年(65岁)未感染艾滋病毒的人收集的相同数据联系在一起，这些人参与了拉什正在进行的三项老龄化队列研究。研究核心对于Rush CEHDA的拟议研究项目和培训工作都是至关重要的，以消除艾滋病毒方面的健康差距，改善感染艾滋病毒的老年少数群体的健康。

PROJECT SUMMARY (See instructions): Due to effective antiretroviral therapy, it is now common for HIV-infected persons to survive into the sixth and seventh decades of life. However, older persons with HIV, defined as those 50 years of age and older, are prematurely experiencing many of the chronic conditions commonly seen in non-infected persons over the age of 70, such as cognitive decline, dementia, physical frailty and other aging-related comorbidities. Emerging data suggest that minorities are disproportionately affected by these premature chronic conditions, yet there have been few studies to characterize and treat these chronic conditions of aging in this population. Eliminating racial disparities in older persons with HIV will require new knowledge about the effects of HIV infection on aging-related comorbidities in minorities. There are relatively few available sources of clinical data and biospecimens from well-characterized older minorities with HIV that can be used to examine racial disparities in health. To fill this gap and address a burgeoning public health problem, the Rush CEDHA Research Core will recruit and enroll a unique cohort of older minority and non-minority persons with and without HIV to provide a source of longitudinal clinical data and biologic specimens. These data will be stored, catalogued, and made available through a repository to local and national investigators to support high quality, cutting edge clinical and basic science studies that focus on the intersection of HIV and aging. Further, these data will be linked to identical data collected from older (>65 years) HIV-uninfected persons of African American and Caucasian backgrounds participating in three ongoing cohort studies of aging at Rush. The Research Core is essential for both the proposed research projects and training efforts of the Rush CEHDA to eliminate health disparities in HIV and improve the health of older minorities infected with HIV.