DIET AND GENOTYPE IN PRIMATE ATHERSCLEROSIS: VETERINARY SERVICES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是项目“灵长类动脉粥样硬化的饮食和基因类型”的一部分，SPID 0044。 核心单元C负责维护纯种狒狒群体，管理繁殖群体，并使用狒狒进行实验程序。群体维护包括日常护理，即喂食指定的饲料、清理笼子、观察动物是否有疾病迹象、治疗生病的动物以及维护动物数据库记录。繁殖群体的管理包括维护母坝分配、监测水坝是否怀孕、在动物数据库中记录出生情况，以及从群体中淘汰非繁殖力的动物。实验程序包括给予高胆固醇、高脂肪饮食挑战、采血、股动脉活检、肝脏活检、肌肉活检、脂肪组织活检和血流介导的血管扩张。动物饲养员负责日常的动物养护工作。兽医或兽医技术员提供医疗保健，准备实验饮食，并负责实验程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is part of the Program Project "Diet and Genotype in Primate Atherosclerosis", SPID 0044. Core Unit C is responsible for maintaining the pedigreed baboon colony, managing the breeding groups, and conducting the experimental procedures using baboons. Colony maintenance includes daily care, i.e., feeding assigned diets, cleaning cages, observing animals for signs of illness, treating sick animals, and maintaining animal database records. Breeding colony management includes maintaining sire-dam assignments, monitoring dams for pregnancies, recording births in the animal database, and culling unproductive animals from the colony. Experimental procedures include administration of the high cholesterol, high fat dietary challenge, blood collections, femoral artery biopsies, liver biopsies, muscle biopsies, adipose tissue biopsies, and flow mediated vasodilation. Animal caretakers are responsible for animal maintenance on a daily basis. Veterinarians or veterinary technicians provide health care, prepare experimental diet, and are responsible for experimental procedures.