A clinical application of Collagen gel

透明质酸在人工晶状体植入手术中被用作粘弹性材料。本研究旨在探讨胶原凝胶在手术和人工晶状体植入术中应用的可能性。另一方面，硅油在完成视网膜脱离手术中使用的频率越来越高，但由于偶尔出现并发症，硅油并不是理想的玻璃体替代品。研究了胶原凝胶作为玻璃体替代物临床应用的可能性。我们使用的粘弹性材料是2%的无继发性热原和抗原性较低的小牛皮肤胶原胶。动物实验后，使用胶原胶进行人工晶状体手术。与透明质酸相比，胶原凝胶的涂布性和润湿性更好，在可操作性方面没有观察到差异。认为胶原蛋白凝胶在人工晶状体植入手术中是有用的似乎是合乎逻辑的。作为玻璃体的替代品，动物研究表明，进一步的研究表明，这种材料具有更高的表面张力和更低的抗原性。

Hyaluronic acid has been used as a viscoelastic material in intraocular lens (IOL) implantation surgery. The studies were carried out the investigate the possibility of collagen gel as operation and during IOL implantation procedure.On the other hand, silicon oil has been used in increased frequency for completed retinal detachment surgery, however, it is not an ideal vitreous substitute because of occasional complications. The possibility of clinical use of collagen gel as vitreous substitute was studied.The viscoelastic material we used was 2% succinglated pyrogen free and less antigenicity collagen gel from calf skin. Following animal study, IOL surgery was performed using collagen gel. Collagen gel was superior in terms of spreadability and wettability as compared to that of hyaluronie acid, and no differences was observed in manoeuvability. It seemed to be logical to assume the collagen gel is useful in IOL implantation surgery. As a vitreous substitute, animal studies revealed that further investigation to develop this material having more surface tension and less antigenicity.