A clinical application of Collagen gel

胶原蛋白凝胶的临床应用

• 批准号: 62570803
• 负责人: TANAKA Minoru
• 金额: $ 1.41万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570803/
• 关键词: Collagen gel; Intraocular Lens; Vitreous Surgery; Succinylation; コラーゲンゲル; 人工水晶体移植術; 代用硝子体

Hyaluronic acid has been used as a viscoelastic material in intraocular lens (IOL) implantation surgery. The studies were carried out the investigate the possibility of collagen gel as operation and during IOL implantation procedure.On the other hand, silicon oil has been used in increased frequency for completed retinal detachment surgery, however, it is not an ideal vitreous substitute because of occasional complications. The possibility of clinical use of collagen gel as vitreous substitute was studied.The viscoelastic material we used was 2% succinglated pyrogen free and less antigenicity collagen gel from calf skin. Following animal study, IOL surgery was performed using collagen gel. Collagen gel was superior in terms of spreadability and wettability as compared to that of hyaluronie acid, and no differences was observed in manoeuvability. It seemed to be logical to assume the collagen gel is useful in IOL implantation surgery. As a vitreous substitute, animal studies revealed that further investigation to develop this material having more surface tension and less antigenicity.

透明质酸已被用作眼内透镜（IOL）植入手术中的粘弹性材料。本研究旨在探讨胶原凝胶作为手术材料和人工晶状体植入术的可行性，而硅油作为玻璃体替代物在视网膜脱离手术中的应用越来越多，但由于其并发症的发生率较高，并不是一种理想的玻璃体替代物。探讨胶原凝胶作为玻璃体替代物临床应用的可能性，所用的粘弹性材料为2%琥珀酰化无热原、低抗原性的小牛皮肤胶原凝胶。动物研究后，使用胶原凝胶进行IOL手术。与透明质酸相比，胶原凝胶在铺展性和润湿性方面是上级的，并且在可操作性方面没有观察到差异。假设胶原凝胶在IOL植入手术中有用似乎是合乎逻辑的。作为玻璃体替代物，动物研究表明，进一步研究开发具有更高表面张力和更低抗原性的材料。

项目成果

TANAKA,M et al: "The studies on collagen gel as viscoelastic material" proc.International Congress of ophthalmology. 62 (1990)

TANAKA,M 等人：“胶原凝胶作为粘弹性材料的研究”，国际眼科大会。

NAKAGAWA,M and TANAKA,M: "The studies on collagen gel as vitreous substitute" proc.International Congress of ophthalmology. 26. 166 (1990)

NAKAGAWA,M 和 TANAKA,M：“胶原凝胶作为玻璃体替代物的研究”，国际眼科大会。

TANAKA, M et al: "The studies on Collagen gel as Vitreous substitute" Fole ophthalmol, Jap 40:1036-1042, 1990.

TANAKA, M 等人：“胶原凝胶作为玻璃体替代品的研究”Fole ophamol，Jap 40：1036-1042，1990。

田中稔 他: 日本眼科学会雑誌(supl). 91. 101 (1987)

Minoru Tanaka 等人：日本眼科学会杂志（增刊）91. 101 (1987)。

TANAKA,M etal.: Arch. ophthalmcl.

田中金属等人：Arch。