HIGH RESOLUTION OPTICAL DIAGNOSTICS FOR ORAL AND LUNG CANCER

口腔癌和肺癌的高分辨率光学诊断

• 批准号: 8362607
• 负责人: ZHONGPING CHEN
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362607
• 关键词: Animal Model; Biotechnology; Blood capillaries; Cancer Detection; Detection; Development; Diagnosis; Diagnostic; Evaluation; Fluorescence; Funding; Grant; Image; Investigation; Lasers; Life; Location; Lung; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Methods; Microcirculation; Monitor; Mouth Neoplasms; National Center for Research Resources; Optical Coherence Tomography; Optics; Oral; Oral Diagnosis; Oral mucous membrane structure; Patients; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Sapphire; Smoking; Source; Structure; Techniques; Time; Tissues; Tobacco; United States National Institutes of Health; capillary; cost; flexibility; improved; in vivo; malignant mouth neoplasm; mortality; optical imaging; tomography; tumor; ultra high resolution

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Smoking induced endobronchial and oral cancers are leading causes of tobacco induced mortality. More accurate methods for diagnosis are needed to improve treatment and survival. We are developing-high resolution (near histological level) flexible fiberoptic endoscopic optical coherence tomographic methods for oral and airway cancer detection and monitoring. Optical coherence tomography (OCT) and optical Doppler tomography use interferometric broad-band coherent gating reflectance techniques to obtain high resolution structural and capillary flow dynamics at defined high resolution spatial locations even in highly scattering tissues like oral mucosa and airways. The 2-10 um OCT resolution capabilities enable us to begin investigation of non-invasive optical imaging of in-vivo tissue structure and microcirculation for diagnosis of oral and airway cancers. We propose to improve diagnosis and treatment of smoking induced airway and oral cancers by further development of flexible fiberoptic OCT/ODT for pulmonary and oral oncologic applications. Specific Aims: 1. To develop real-time flexible fiberoptic bronchoscopic methods for high-resolution simultaneous OCT/ODT evaluation of airway and oral tumors. 2. Evaluate these OCT/ODT capabilities for identifying oral cancers in live animal models and airway cancers in patients with smoking induced airway malignancy. 3. Assess the potential for combining low resolution in-vivo tumor fluorescence localization with OCT/ODT high resolution imaging to improve diagnostic yield and detection efficiency for oral and airway cancers, and to better understand functional optical markers for malignant transformation. 4. Develop methods for ultra-high resolution Ti:sapphire in-vivo OCT imaging.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 吸烟引起的支气管内癌和口腔癌是烟草引起的死亡的主要原因。 需要更准确的诊断方法来改善治疗和生存率。 我们正在开发用于口腔和气道癌症检测和监测的高分辨率（接近组织学水平）柔性光纤内窥镜光学相干断层扫描方法。 光学相干断层扫描（OCT）和光学多普勒断层扫描使用干涉宽带相干选通反射技术来在限定的高分辨率空间位置处获得高分辨率结构和毛细血管流动动力学，即使在高度散射的组织如口腔粘膜和气道中。 2-10 μ m的OCT分辨率能力使我们能够开始研究用于诊断口腔和气道癌症的体内组织结构和微循环的非侵入性光学成像。 我们建议通过进一步开发用于肺部和口腔肿瘤学应用的柔性光纤OCT/ODT来改善吸烟引起的气道和口腔癌的诊断和治疗。 具体目标： 1. 开发实时柔性纤维支气管镜方法，用于气道和口腔肿瘤的高分辨率同步OCT/ODT评价。 2. 评价这些OCT/ODT在活体动物模型中识别口腔癌和吸烟诱导的气道恶性肿瘤患者中识别气道癌的能力。 3. 评估低分辨率体内肿瘤荧光定位与OCT/ODT高分辨率成像相结合的潜力，以提高口腔和气道癌的诊断率和检测效率，并更好地了解恶性转化的功能性光学标记物。 4. 开发超高分辨率钛宝石体内OCT成像方法。