Phase resolved ARF optical coherence elastography for intravascular imaging

项目总结 心血管疾病每年导致四分之一的死亡，即65万美国人死亡。它是 是美国最大的死因。动脉粥样硬化斑块破裂是急性 冠状动脉事件，这是致命的后果。临床上，及早发现斑块的潜在易损性 是抵御这种致命环境的第一道防线，它依赖于可视化组织结构 和生物力学特性。斑块病变的准确特征有助于更好的治疗 通过加深我们对疾病进展的了解来进行管理。 这项提议的长期目标是开发一种多模式血管内成像系统，该系统 结合了光学相干层析成像(OCT)、超声成像(US)和基于剪切波的光学 相干弹性成像(OCESW)用于研究和表征斑块易损性。拟议的系统， IVOCT-US-OCESW建立在前面提案中开发的ARF-OCE技术的基础上，具有几个 重大的技术进步，将进一步促进其临床翻译。拟议的IVOCT-US- OCESW系统结合了1.7微米OCT的高空间分辨率和扩展的穿透深度，宽 超声的成像深度和OCESW增强的生物力学对比。它将为医生提供强大的 研究、诊断和管理易损斑块的临床仪器。仅限多模式探测器 只需一根一次性导丝和导尿管，从而降低了成本、手术长度、关联 风险和X光暴露。我们的具体目标是：1)设计和构建一个多通道IVOCT-US-OCESW 成像探头；2)开发IVOCT-US-OCESW系统，采用4 MHz，1.7微米激光；3)建立 生物力学性能量化的扫描方案和算法；4)展示了 在正常动物模型和疾病动物模型中建议的系统。 我们期待着建议的高速、高渗透深度和高灵敏度的发展 IVOCT-US-OCESW系统和探测对基础科学和临床理解都有重大影响 斑块的发病机制。这将增强临床医生识别脆弱病变、量身定做介入治疗的能力 治疗，并监测疾病的进展。更重要的是，它将是一个强大的工具，提供了一个量化的 对新的医疗设备和疗法进行基准测试和评估的手段。

PROJECT SUMMARY Cardiovascular disease is responsible for 1 in 4 deaths, or 650,000 Americans, every year. It is the leading cause of death in the United States. Ruptured atherosclerotic plaques are the main cause of acute coronary events, and it is of lethal consequence. Clinically, early detection of the latent vulnerability of plaques is the first line of defense against such deadly circumstances, and it relies on visualizing both tissue structural and biomechanical properties. Accurate characterization of a plaque lesion can facilitate better treatment management by further our understanding in the disease progression. The long-term objective of this proposal is to develop a multimodal intravascular imaging system that combines optical coherence tomography (OCT), ultrasound imaging (US), and shear-wave-based optical coherence elastography (OCESW) for studying and characterizing plaque vulnerability. The proposed system, IVOCT-US-OCESW, is built upon the ARF-OCE technology developed in the preceding proposal, with several significant technical advancements that will further facilitate its clinical translation. The proposed IVOCT-US- OCESW system unifies the high spatial resolution and extended penetration depth of the 1.7-µm OCT, the broad imaging depth of US, and the enhanced biomechanical contrast of OCESW. It will provide physicians a powerful clinical instrument for studying, diagnosing, and managing vulnerable plaques. The multimodal probe only requires a single disposable guide wire and catheter, thereby reducing the costs, procedure length, associated risks, and X-ray exposure. Our specific aims are to: 1) Design and construct a multimodal IVOCT-US-OCESW imaging probe; 2) Develop the IVOCT-US-OCESW system featuring a 4-MHz, 1.7-µm laser; 3) Establish a scanning protocol and algorithms for biomechanical property quantification; 4) Demonstrate the efficacy of the proposed system in normal and diseased animal models. We expect the development of the proposed high-speed, high-penetration-depth, and high-sensitivity IVOCT-US-OCESW system and probe to have significant impact to both basic science and clinical understanding of plaque pathogenesis. This will enhance the clinicians’ ability to identify vulnerable lesions, tailor interventional therapy, and monitor disease progression. More importantly, it will be a powerful tool that provides a quantitative means to benchmark and evaluate new medical devices and therapies.