ROLE OF MECHANICAL FORCE IN NOTCH SIGNALING

机械力在陷波信号中的作用

• 批准号: 8362698
• 负责人: ELIAS BOTVINICK
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362698
• 关键词: Adhesions; Avidity; Biotechnology; Cells; Funding; Grant; Lasers; Ligands; Measures; Mechanics; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Role; Signal Transduction; Source; United States National Institutes of Health; cost; laser tweezer; notch protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SMM laser tweezers used to measure endocytic forces and avidity between Notch coated beads and ligand expressing cells. Correlations between endocytic forces, adhesion strength and Notch transedocytoiss are sought

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 SMM 激光镊子用于测量 Notch 涂层珠子和配体表达细胞之间的内吞力和亲合力。寻找内吞力、粘附强度和Notch转胞吞之间的相关性