STUDIES OF SHEAR STRESS ON CELLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 内皮细胞的功能和形态受剪应力的调节。 在这个项目中，旋转的微粒将产生一个小的层流流场。不同类型的微粒将被测试以获得适合于产生局部高剪应力的旋转速度。荧光成像技术将用于监测细胞对压力的动态反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Function and morphology of endothelial cells are regulated by shear stress. In this project a small laminar flow field will be created by rotating microparticles. Different type of microparticles will be tested for achieving a rotation rate suitable for creating a locally high shear stress. Fluorescence imaging techniques will be used for monitoring the dynamic responses of the cells to stress.