STUDIES OF SHEAR STRESS ON CELLS

细胞剪切应力的研究

• 批准号: 8362650
• 负责人: ELIAS BOTVINICK
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362650
• 关键词: Biotechnology; Cells; Endothelial Cells; Funding; Grant; Imaging Techniques; Lasers; Monitor; Morphology; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Rotation; Source; Stress; Testing; United States National Institutes of Health; cost; fluorescence imaging; response; shear stress

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Function and morphology of endothelial cells are regulated by shear stress. In this project a small laminar flow field will be created by rotating microparticles. Different type of microparticles will be tested for achieving a rotation rate suitable for creating a locally high shear stress. Fluorescence imaging techniques will be used for monitoring the dynamic responses of the cells to stress.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 内皮细胞的功能和形态受切应力的调节。 在这个项目中，一个小的层流场将通过旋转微粒。将测试不同类型的微粒以实现适于产生局部高剪切应力的旋转速率。荧光成像技术将用于监测细胞对压力的动态反应。