VEGF ACTIVITY MONITORED WITH OPTICAL MICROSCOPY FOLLOWING SELECTIVE LASER INJURY

选择性激光损伤后用光学显微镜监测 VEGF 活性

• 批准号: 7954887
• 负责人: ELIAS BOTVINICK
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954887
• 关键词: Biotechnology; Clinical; Computer Retrieval of Information on Scientific Projects Database; Dorsal; Funding; Grant; Institution; Intervention; Knowledge; Laser injury; Lasers; Microscopy; Modeling; Monitor; Mus; Optics; Pharmaceutical Preparations; Port-Wine Stain; Protocols documentation; Research; Research Personnel; Resources; Schedule; Source; Therapeutic; Transgenic Organisms; Treatment Protocols; United States National Institutes of Health; Vascular Endothelial Growth Factors; base; improved; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Can VEGF activity be monitored with optical microscopy following selective laser injury? We are interested in developing combination therapeutic protocols involving light-based and drug-based interventions, for enhanced clinical therapy of port wine stain birthmarks. Knowledge of VEGF activity would improve our ability to schedule properly the treatment protocols. We will employ multiphoton microscopy to study the VEGF activity in the mouse dorsal window chamber model. We will use transgenic VEGF-GFP mice.

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