VEGF ACTIVITY MONITORED WITH OPTICAL MICROSCOPY FOLLOWING SELECTIVE LASER INJURY

选择性激光损伤后用光学显微镜监测 VEGF 活性

• 批准号: 8169514
• 负责人: ELIAS BOTVINICK
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169514
• 关键词: Clinical; Computer Retrieval of Information on Scientific Projects Database; Dorsal; Funding; Grant; Institution; Intervention; Knowledge; Laser injury; Microscopy; Modeling; Monitor; Mus; Optics; Pharmaceutical Preparations; Port-Wine Stain; Protocols documentation; Research; Research Personnel; Resources; Schedule; Source; Therapeutic; Transgenic Organisms; Treatment Protocols; United States National Institutes of Health; Vascular Endothelial Growth Factors; base; improved; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Can VEGF activity be monitored with optical microscopy following selective laser injury? We are interested in developing combination therapeutic protocols involving light-based and drug-based interventions, for enhanced clinical therapy of port wine stain birthmarks. Knowledge of VEGF activity would improve our ability to schedule properly the treatment protocols. We will employ multiphoton microscopy to study the VEGF activity in the mouse dorsal window chamber model. We will use transgenic VEGF-GFP mice.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 选择性激光损伤后能否用光学显微镜监测血管内皮生长因子的活性？ 我们有兴趣开发包括基于光的干预和基于药物的干预的联合治疗方案，以加强对鲜红斑斑胎记的临床治疗。了解血管内皮生长因子的活性将提高我们正确安排治疗方案的能力。我们将使用多光子显微镜来研究血管内皮生长因子在小鼠背侧窗房模型中的活性。我们将使用转基因血管内皮生长因子-绿色荧光蛋白小鼠。