VEGF ACTIVITY MONITORED WITH OPTICAL MICROSCOPY FOLLOWING SELECTIVE LASER INJURY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在选择性激光损伤后可以用光学显微镜监测VEGF活性吗？ 我们有兴趣开发组合治疗方案，包括基于光和基于药物的干预，以增强葡萄酒色斑胎记的临床治疗。 了解VEGF活性将提高我们合理安排治疗方案的能力。 我们将采用多光子显微镜研究小鼠背侧窗室模型中VEGF的活性。 我们将使用转基因VEGF-GFP小鼠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Can VEGF activity be monitored with optical microscopy following selective laser injury? We are interested in developing combination therapeutic protocols involving light-based and drug-based interventions, for enhanced clinical therapy of port wine stain birthmarks. Knowledge of VEGF activity would improve our ability to schedule properly the treatment protocols. We will employ multiphoton microscopy to study the VEGF activity in the mouse dorsal window chamber model. We will use transgenic VEGF-GFP mice.