TWO-LASER FPOP AND PROTEIN FOLDING
TWO-LASER FPOP AND PROTEIN FOLDING
批准号:
8361410
负责人:
MICHAEL L GROSS
金额:
$2.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-01-01 至 2011-12-31
关键词:
FundingGrantHeatingLabelLasersMass Spectrum AnalysisMethodsNational Center for Research ResourcesPrincipal InvestigatorProtein DynamicsProtein FootprintingProteinsResearchResearch InfrastructureResourcesSourceSystemTimeUnited States National Institutes of Healthbiomedical resourcecostprotein folding
中文摘要
这个子项目是利用资源的许多研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 为子项目列出的总成本可能
表示子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
利用FPOP作为快速标记策略,我们正在构建一个双激光系统,该系统利用Nd:YAG激光器和拉曼移位器来快速加热蛋白质,然后使用第二激光器来产生自由基以在展开过程中覆盖蛋白质。 这种方法将使我们能够在微秒的时间尺度上探测蛋白质动力学。
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Taking advantage of FPOP as a fast labeling strategy, we are building a two laser system that utilizes a Nd:YAG laser and a Raman shifter to quickly heat a protein, and then use the second laser to generate radicals to footprint the protein during unfolding. This method will allow us to probe protein dynamics on a microsecond time scale.
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会议论文
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批准号:10441142
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项目类别:
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资助金额:$65.99万
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财政年份:2020
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负责人:MICHAEL L GROSS
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依托单位:
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批准号:10350642
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项目类别:
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资助金额:$40.98万
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财政年份:2019
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负责人:MICHAEL L GROSS
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依托单位:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID
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批准号:10390166
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项目类别:
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资助金额:$25.0万
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财政年份:2019
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负责人:MICHAEL L GROSS
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依托单位:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS
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批准号:10587527
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项目类别:
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资助金额:$46.57万
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财政年份:2019
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负责人:MICHAEL L GROSS
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依托单位:
A MASS SPECTROMETER FOR PROTEIN FOOTPRINTING
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批准号:8637341
-
项目类别:
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资助金额:$44.99万
-
财政年份:2014
-
负责人:MICHAEL L GROSS
-
依托单位:
APPROACHES TO IMPROVE PROTEIN FOOTPRINTING: HIGH PRESSURE DIGESTION
-
批准号:8361405
-
项目类别:
-
资助金额:$1.57万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
HIGH ENERGY COLLISIONAL ACTIVATION
-
批准号:8361422
-
项目类别:
-
资助金额:$0.63万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
UNDERGRADUATE TRAINING IN MASS SPECTROMETRY
-
批准号:8361432
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项目类别:
-
资助金额:$0.2万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
VISITING SCIENTISTS
-
批准号:8361338
-
项目类别:
-
资助金额:$0.52万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
STRUCTURAL STUDIES OF GRAMICIDIN & OTHER SELF-ASSOCIATING PEPTIDES
-
批准号:8361321
-
项目类别:
-
资助金额:$0.31万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
CONTRIBUTED PRESENTATIONS AT CONFERENCES
-
批准号:8361333
-
项目类别:
-
资助金额:$2.11万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
INVITED LECTURES AT UNIVERSITIES & CONFERENCES
-
批准号:8361336
-
项目类别:
-
资助金额:$0.74万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
TOXICOLOGICAL EFFECTS OF QUINONES
-
批准号:8361377
-
项目类别:
-
资助金额:$1.26万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
DEVELOPMENT AND APPLICATION OF PLIMSTEX
-
批准号:8361324
-
项目类别:
-
资助金额:$3.8万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
CONSULTING FOR NCRR AND NIBIB RESOURCES
-
批准号:8361475
-
项目类别:
-
资助金额:$0.43万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
DEVELOPMENT OF PROTEIN TOOL BOX SOFTWARE MODULES
-
批准号:8361369
-
项目类别:
-
资助金额:$0.63万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
SCIENTIFIC JOURNAL EDITING
-
批准号:8361334
-
项目类别:
-
资助金额:$0.2万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
COMPUTATIONAL METHODS FOR FRAGMENTATION OF BIOMOLECULES - LIPIDS
-
批准号:8361318
-
项目类别:
-
资助金额:$0.79万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
ENCYCLOPEDIA OF MASS SPECTROMETRY
-
批准号:8361339
-
项目类别:
-
资助金额:$0.2万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
SEPARATION METHODS FOR COMPLEX MIXTURES
-
批准号:8361351
-
项目类别:
-
资助金额:$0.94万
-
财政年份:2011
-
负责人:MICHAEL L GROSS
-
依托单位:
海外基金