DEVELOPMENT OF SUB-SECOND 3D PULSE SEQUENCES FOR FMRI IN NEUROSCIENCE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 用于绘制皮质柱的高分辨率功能磁共振成像(FMRI)的开发是3D的。功能磁共振成像是一种广泛使用的方法，用于在大脑执行思维任务时研究大脑，并绘制大脑活动的区域。我们正在提出一种亚秒3D成像技术，以补充或取代目前使用的亚秒2D成像功能磁共振成像。3D功能磁共振成像将有助于揭示大脑活动的基本组织，这可能会导致对大脑如何工作的新发现。通过3D fMRI在大脑中获得的测量结果将有助于包括阿尔茨海默病在内的神经退行性疾病的研究、药物试验以及对中风和脑血管疾病患者的评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development of high resolution functional MRI (fMRI) capabilities for mapping cortical columns is 3D. fMRI is a widely used method to study the brain while it is performing thinking tasks and to map out regions of brain activity. We are proposing a sub-second 3D imaging technology to be supplement or replace the current use of sub-second 2D imaging for fMRI. The 3D fMRI will be useful for revealing the basic organization of the brain's activity which could lead to new discoveries of how the brain works. The resulting measurements obtained in the brain with 3D fMRI will be useful for studies of neurodegenerative diseases including Alzheimer's disease, drug trials and for evaluating people with stroke and cerebrovascular diseases.