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INTRACELLULAR RNA TRAFFICKING

INTRACELLULAR RNA TRAFFICKING
细胞内 RNA 运输
批准号：
8362485
负责人：
JOHN H CARSON
金额：
$5.27万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-05-01 至 2012-04-30
来源：
https://reporter.nih.gov/project-details/8362485
关键词：
BindingCell modelCellsComplexFluorescenceFundingGrantIn VitroLifeMapsMeasuresModelingNational Center for Research ResourcesNeuronsPrincipal InvestigatorProcessRNAResearchResearch InfrastructureResourcesSourceSpectrum AnalysisSurface Plasmon ResonanceSystemTechniquesUnited States National Institutes of Healthcostin vivotraffickingvirtual

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中文摘要
翻译
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. RNA trafficking is a complex process whereby specific RNAs are localized to particular subcellular compartments. Through a variety of in vivo and in vitro techniques we have delineated a molecular interaction map describing the RNA trafficking system in neural cells. We have measured quantitative parameters for each molecular interaction in RNA trafficking using surface plasmon resonance analysis in vitro and fluorescence correlation spectroscopy (FCS) and in live cells. Quantitative parameters are used in Virtual Cell models of RNA trafficking.
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