Translational Pathology and Imaging

翻译病理学和成像(TPI)核心提供高质量的生物显微镜、研究组织学服务和成像服务，以支持孢子的翻译工作。Core Bank将人类大肠肿瘤和匹配的正常组织样本分发给Vanderbilt Gl孢子和其他Gl孢子的研究人员，并将息肉和大体正常大肠粘膜的活检部分交给研究人员，以促进腺瘤复发的研究(项目4)。详细的生物标本注释，包括组织病理学特征、分析前变量、组织质量指标和临床结果，记录在由生物统计和生物信息学核心支持和维护的关系数据库中。核心遵循严格的质量保证计划，以确保生物样品和数据质量。其他服务包括研究免疫组织化学、解释小鼠和人类的组织病理学结果、定制组织微阵列设计，以及激光捕获显微镜的咨询服务。该中心通过使用明确的同意书来保护患者的机密性，该同意书专门针对用于研究目的的无关组织的使用，并通过取消标本的识别来实现。VUMC的Gl孢子组织核心在华盛顿博士的指导下与VUMC的其他组织收集机制、消化疾病研究中心的组织形态次核心以及VUMC领导的合作人体组织网络西部部门合作，以经济高效的方式提供这些服务。 该核心将为所有四个孢子项目提供病理学支持，并将与生物统计和生物信息学核心合作。

The Translational Pathology and Imaging (TPI) Core provides high quality biospecimens, research histology services, and imaging services to support the translational efforts of the SPORE. The Core banks and distribute human colorectal neoplasms and matched normal tissue samples to investigators in the Vanderbilt Gl SPORE and other Gl SPORES and banks portions of polyps and biopsies of grossly normal colorectal mucosa to facilitate research in adenoma recurrence (Project 4). Detailed biospecimen annotation, including histopathologic features, preanalytical variables, tissue quality metrics, and clinical outcome is recorded in relational databases supported and maintained by the Biostatistics and Bioinformatics Core. The Core follows a rigorous quality assurance program to ensure biospecimen and data quality. Other services include research immunohistochemistry, interpretation of mouse and human histopathologic findings, custom tissue microarray design, and consultative services for laser capture microscopy. The Core protects patient confidentiality through use of an explicit consent form that specifically addresses use of extraneous tissue for research purposes and through de-identification of specimens. The Gl SPORE Tissue Core at VUMC has partnered with other mechanisms for tissue collection at VUMC under Dr. Washington's direction, the Tissue Morphology SubCore of the Digestive Disease Research Center, and the VUMC-led Western Division of the Cooperative Human Tissue Network to provide these services in a cost-effective manner. This Core will provide pathology support to all four SPORE projects and will collaborate with the Biostatistics and Bioinformatics Core.