Tennessee Valley Cooperative Human Tissue Network

田纳西谷合作人体组织网络

• 批准号: 8669436
• 负责人: MARY Kay WASHINGTON
• 金额: $ 98.12万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8669436
• 关键词: Advocate; Awareness; Basic Science; Biomedical Research; Businesses; Clinical; Collection; Communication; Communities; Complex; Computer software; Confidentiality of Patient Information; Cooperative Human Tissue Network; DNA; Data Set; Development; Disease; Education; Funding; Generations; Goals; Health; Healthcare; Human; Individual; Informatics; Informed Consent; Link; Malignant Neoplasms; Marketing; Modeling; Patients; Play; Procedures; Process; Public Health; Qualifying; Quality Control; RNA; Rare Lesion; Recording of previous events; Research; Research Personnel; Resources; Role; Services; Solid; Source; Specimen; System; Tennessee; Tissue Microarray; Tissue Sample; Tissues; Translational Research; base; biobank; cost effective; experience; human disease; human tissue; improved; innovation; member; neoplastic; operation; programs; prospective; tumor; tumor progression; web services

DESCRIPTION (provided by applicant): The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source of human tissues to support biomedical research. As the Western Division of the CHTN, we propose to continue to serve the scientific community by procuring and distributing biospecimens in an efficient, cost-effective manner. The specific aims of this application are: 1) To collect, process and distribute high quality human solid tissue and biofluid specimens with appropriate clinical annotation to qualified researchers on a prospective basis; 2) To apply a rigorous Quality Management System to all aspects of the program; 3) To provide tumor macrodissection, tissue microarray "build on demand" and RNA/DNA extraction services, as requested; 4) To collect and bank pre-neoplastic and rare lesions to facilitate basic research in tumor progression and early translational research; 5) To protect patient confidentiality by obtaining informed consent for collection of extraneous tissue and biofluids for research, and through de-identification of specimens, and by continuing to partner with VUMC patient advocates to engage patients and provide opportunities for participation in research; 6) To develop and integrate new business models and informatics (IT) strategies that improve operational efficiency, by developing a third generation network Investigator IT system for request sharing; 7) To develop innovative internal IT programs by partnering with VUMC BioVu project to link tissue samples to large clinical datasets, and by providing an internal mechanism for research results sharing at VUMC as a pilot program; 8) To expand CHTN marketing and education efforts through strategies to increase awareness in the scientific community. In 12 years as a CHTN Division, we have been an innovative and highly productive member of the network, distributing over 63,170 specimens to 723 investigators in the last 5 years. We have developed critical SOPs and integrative biorepository software that have been implemented throughout the CHTN. Our goals in the next funding period include continuing to provide numerous high quality biospecimens and to develop innovative IT programs to improve efficiency and communication within the network and with investigators.

描述(由申请人提供)：自1987年以来，合作人体组织网络(CHTN)作为支持生物医学研究的人体组织来源发挥了重要作用。作为CHTN的西部分部，我们建议继续以高效率、高成本效益的方式采购和分发生物标本，为科学界服务。本申请的具体目标是：1)收集、加工和分配高素质的人才 具有适当临床注释的固体组织和生物液标本将在预期的基础上提供给合格的研究人员；2)将严格的质量管理体系应用于计划的所有方面；3)根据要求提供肿瘤大体解剖、组织微阵列“按需构建”和RNA/DNA提取服务；4)收集和储存肿瘤前和罕见的病变，以促进肿瘤进展的基础研究和早期翻译研究；5)保护患者的机密性，方法是获得收集外来组织和生物液用于研究的知情同意，并通过去鉴定标本，并继续与VUMC患者权益倡导者合作，与患者接触并提供参与研究的机会；6)开发和整合新的商业模式和信息(IT)战略，以提高运营效率，通过开发用于请求共享的第三代网络Investigator IT系统；7)通过与VUMC BioVu项目合作，将组织样本与大型临床数据集联系起来，并作为试点计划，为VUMC的研究结果共享提供内部机制，来开发创新的内部IT计划；8)通过提高科学界认识的战略，扩大CHTN的营销和教育工作。 在作为CHTN部门的12年中，我们一直是该网络的创新和高效成员，在过去5年中向723名调查人员分发了超过63,170份标本。我们已经开发了关键的SOP和集成的生物信息库软件，并已在整个CHTN中实施。我们在下一个资金阶段的目标包括继续提供大量高质量的生物标本，并开发创新的IT计划，以提高网络内和调查人员的效率和沟通。