Tennessee Valley Cooperative Human Tissue Network

项目总结 自1987年以来，合作的人类组织网络(CHTN)作为一种来源发挥了重要作用 用于生物医学研究的人体组织。为此，西部师的首要目标是 范德比尔特大学医学中心(CHTN-VUMC)的CHTN将继续为 社区通过采购和分发成人生物标本，利用严格的质量管理 计划，以维持高效和多产的生物信息库操作。这一目标的关键方面 是临床上定制的高质量固体组织和生物液的预期集合 将严格的质量管理体系诠释和应用到项目的各个方面。 将通过发射另外两个卫星站点进行收集，从而扩大人口覆盖面。新的 单细胞悬液、分离肿瘤浸润性淋巴细胞和TMA等服务建立在 提出了针对不断变化的调查员需求的需求。此外，癌前病变和罕见癌 病变将被存入银行，以促进肿瘤进展的研究。CHTN-VUMC将坚持 严格的道德标准，保护人类受试者和患者的机密性，并将与 与VUMC倡导计划合作，以吸引患者并提供参与 研究。我们还建议作为信息学(IT)跨网络协调中心 负责“调查员IT”系统的第二个版本，利用网络服务和强大的 现代技术先进的平台，并确保遵守IT安全最佳实践。在ITS中 部门IT战略，CHTN-VUMC将开发和整合新的商业模式和新的 提高运营效率的信息学战略，包括与VUMC BioVu合作 将组织样本与大型临床数据集联系起来的项目。营销努力将包括以下举措： 提高科学界对CHTN的认识，包括加强使用社交媒体，以及 CHTN-VUMC将通过在以下领域的领导，为生物信息库科学和教育做出积极贡献 例如国际生物和环境储存库协会。 CHTN-VUMC在网络IT开发方面的领先地位使该部门成为唯一有资格担任 中央IT站点。标本分发的良好记录，有64,358个标本运往 过去6.5年的1011名调查人员，突出了现有CHTN-VUMC的能力 基础设施。CHTN-VUMC在下一个资金期的目标包括在这些基础上 在提高网络、调查人员和科学人员内部的效率和沟通方面取得的成就 社区。

PROJECT SUMMARY The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source for human tissues for biomedical research. To this end, the overarching goal of the Western Division of the CHTN at Vanderbilt University Medical Center (CHTN-VUMC) is to continue to serve the scientific community by procuring and distributing adult biospecimens, utilizing a stringent quality management program to maintain a highly efficient and productive biorepository operation. Key aspects of this goal are the prospective customized collection of high quality solid tissues and biofluids with clinical annotation and application of a rigorous Quality Management System to all aspects of the program. Demographic coverage will be expanded by launching two additional satellite sites for collection. New services, such as single-cell suspensions, isolation of tumor infiltrating lymphocytes and TMA Build On Demand in response to changing investigator needs are proposed. In addition preneoplastic and rare lesions will be banked to facilitate research in tumor progression. The CHTN-VUMC will adhere to rigorous ethical standards for protection of human subjects and patient confidentiality, and will partner with the VUMC advocacy program to engage patients and provide opportunities for participation in research. We also propose to serve as the Informatics (IT) trans-network Coordinating Center responsible for the second version of the “Investigators IT” system, utilizing web services and a strong modern technologically advanced platform and ensuring adherence to IT security best practices. In its divisional IT strategy, CHTN-VUMC will develop and integrate new business models and novel informatics strategies to improve operational efficiency, including partnering with the VUMC BioVu project to link tissue samples to large clinical datasets. Marketing efforts will include initiatives to increase awareness of CHTN in the scientific community, including enhanced use of social media, and CHTN-VUMC will actively contribute to biorepository science and education through leadership in societies such as the International Society for Biological and Environmental Repositories. CHTN-VUMC's leadership in network IT development makes the division uniquely qualified to serve as the central IT site. A robust track record of specimen distribution, with 64,358 specimens shipped to 1011 investigators over the past 6.5 years, highlights the capabilities of the existing CHTN-VUMC infrastructure. CHTN-VUMC goals in the next funding period include building upon these foundational achievements to improve efficiency and communication within the network, investigators and scientific community.