Tennessee Valley Cooperative Human Tissue Network

田纳西谷合作人体组织网络

• 批准号: 10378774
• 负责人: MARY Kay WASHINGTON
• 金额: $ 86.84万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378774
• 关键词: Academic Medical Centers; Achievement; Adherence; Adult; Advocacy; Awareness; Basic Science; Biological; Biomedical Research; Businesses; Cells; Clinical; Collection; Communication; Communities; Complex; Computer software; Confidentiality of Patient Information; Cooperative Human Tissue Network; Custom; Data Set; Development; Disease; Education; Ensure; Ethics; Feedback; Foundations; Funding; Goals; Healthcare; Human; Industry Standard; Informatics; Infrastructure; International; Leadership; Link; Malignant Neoplasms; Marketing; Modeling; Modernization; Patients; Performance; Play; Population; Process; Public Health; Quality Control; Rare Lesion; Regulation; Research; Research Personnel; Role; Security; Services; Ships; Site; Societies; Solid; Source; Specimen; Suspensions; System; Tennessee; Thinness; Tissue Sample; Tissues; Translational Research; Tumor-Infiltrating Lymphocytes; biobank; cost effective; design; experience; human disease; human subject protection; human tissue; improved; individual patient; innovation; member; neoplastic; network informatics; novel; operation; programs; prospective; repository; response; satisfaction; science education; social media; tumor progression; web services

PROJECT SUMMARY The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source for human tissues for biomedical research. To this end, the overarching goal of the Western Division of the CHTN at Vanderbilt University Medical Center (CHTN-VUMC) is to continue to serve the scientific community by procuring and distributing adult biospecimens, utilizing a stringent quality management program to maintain a highly efficient and productive biorepository operation. Key aspects of this goal are the prospective customized collection of high quality solid tissues and biofluids with clinical annotation and application of a rigorous Quality Management System to all aspects of the program. Demographic coverage will be expanded by launching two additional satellite sites for collection. New services, such as single-cell suspensions, isolation of tumor infiltrating lymphocytes and TMA Build On Demand in response to changing investigator needs are proposed. In addition preneoplastic and rare lesions will be banked to facilitate research in tumor progression. The CHTN-VUMC will adhere to rigorous ethical standards for protection of human subjects and patient confidentiality, and will partner with the VUMC advocacy program to engage patients and provide opportunities for participation in research. We also propose to serve as the Informatics (IT) trans-network Coordinating Center responsible for the second version of the “Investigators IT” system, utilizing web services and a strong modern technologically advanced platform and ensuring adherence to IT security best practices. In its divisional IT strategy, CHTN-VUMC will develop and integrate new business models and novel informatics strategies to improve operational efficiency, including partnering with the VUMC BioVu project to link tissue samples to large clinical datasets. Marketing efforts will include initiatives to increase awareness of CHTN in the scientific community, including enhanced use of social media, and CHTN-VUMC will actively contribute to biorepository science and education through leadership in societies such as the International Society for Biological and Environmental Repositories. CHTN-VUMC's leadership in network IT development makes the division uniquely qualified to serve as the central IT site. A robust track record of specimen distribution, with 64,358 specimens shipped to 1011 investigators over the past 6.5 years, highlights the capabilities of the existing CHTN-VUMC infrastructure. CHTN-VUMC goals in the next funding period include building upon these foundational achievements to improve efficiency and communication within the network, investigators and scientific community.

项目概要 自 1987 年以来，人体组织合作网络 (CHTN) 作为信息来源发挥了重要作用 用于生物医学研究的人体组织。为此，西部赛区的总体目标 范德比尔特大学医学中心 (CHTN-VUMC) 的 CHTN 将继续为科学界提供服务 通过采用严格的质量管理采购和分发成人生物样本来社区 维持高效且富有成效的生物样本库运行的计划。这一目标的关键方面 是具有临床意义的高质量实体组织和生物流体的前瞻性定制集合 将严格的质量管理体系注释和应用到项目的各个方面。 将通过发射另外两个卫星收集站来扩大人口覆盖范围。新的 服务，例如单细胞悬浮液、肿瘤浸润淋巴细胞的分离和 TMA Build On 提出了响应不断变化的研究者需求的需求。此外，癌前和罕见 病变将被储存起来以促进肿瘤进展的研究。 CHTN-VUMC 将坚持 保护人类受试者和患者机密的严格道德标准，并将与合作伙伴 与 VUMC 倡导计划一起吸引患者并提供参与机会 研究。我们还建议充当信息学（IT）跨网络协调中心 负责“Investigators IT”系统的第二版，利用网络服务和强大的 现代技术先进的平台，并确保遵守 IT 安全最佳实践。在其 CHTN-VUMC 将根据部门 IT 战略开发和整合新的业务模式和新颖的 提高运营效率的信息学策略，包括与 VUMC BioVu 合作 将组织样本链接到大型临床数据集的项目。营销工作将包括以下举措： 提高科学界对 CHTN 的认识，包括加强社交媒体的使用，以及 CHTN-VUMC 将通过在以下领域的领导力，积极为生物样本库科学和教育做出贡献： 国际生物与环境保藏协会等协会。 CHTN-VUMC 在网络 IT 开发方面的领先地位使该部门具有独一无二的资格 中央 IT 站点。样本分发的稳健记录，已运送 64,358 个样本 过去 6.5 年的 1011 名调查员，凸显了现有 CHTN-VUMC 的功能 基础设施。 CHTN-VUMC 下一个资助期的目标包括以这些基础为基础 提高网络、研究人员和科学人员的效率和沟通的成就 社区。