Gastric Histopathology Core

胃组织学核心的主要使命是提供高质量，快速周转的组织学 和免疫组织化学服务，并提供专家组织病理学 通过与凯华盛顿博士的合作，建议提供下列服务： 1.为PPG研究者提供高质量、快速周转的研究组织学服务。 2.目的：为啮齿类动物H.幽门诱发性胃肿瘤 与人类疾病的关系。 3.在动物免疫组织化学研究的开发、实施和评估方面提供专业知识 组织中 4.提供激光显微切割服务。 5.执行质量控制，以确保组织学和免疫组织化学服务是最高的 质量. 6.提供组织微阵列服务，并根据需要获取人类胃组织样本。 这三个组成项目和核心B（蛋白质组学核心）的建议计划项目都依赖于 严重依赖于从幽门螺杆菌诱导的啮齿动物模型中分离的胃组织的形态学分析 胃炎和胃肿瘤。华盛顿医生在解释组织病理学方面的专业知识 啮齿动物模型和免疫组织化学研究解释的变化对这项工作至关重要， 而这项合作活动目前没有通过现有资源供资。通过利用 一个成熟的研究组织学设施，用于组织储存、处理、切割组织块和染色， 幻灯片，将有可能达到高标准的所有组织学研究提出了这项赠款。这 在外科病理学家的监督下集中组织学服务， 胃肠道病理学将允许仔细注意质量保证。

The primary mission of the Gastric Histopathology Core is to provide high quality, rapid-turnaround histology and immunohistochemistry services to investigators in this PPG, and to provide expert histopathologic nterpretation, through collaboration with Dr. Kay Washington. The following services are proposed: 1. To provide high quality, rapid-turnaround research histology services to PPG investigators. 2. To provide expert evaluation of histopathology of rodent models of H. pylori-Induced gastric neoplasia and correlation with human disease. 3. To provide expertise in developing, performing and evaluating immunohistochemical studies on animal tissues. 4. To provide laser microdissection services. 5. To perform quality control to ensure that histology and immunohistochemistry services are of highest quality. 6. To provide tissue microarray services and access to human gastric tissue samples as needed. The three component projects and Core B (Proteomics Core) of this proposed Program Project all rely heavily upon morphologic analysis of gastric tissues isolated from rodent models of Helicobacter pyloriinduced gastritis and gastric neoplasia. Dr. Washington's expertise in interpretation of histopathologic changes in rodent models and in interpretation of immunohistochemical studies will be critical to this work, and this collaborative activity is currently not funded through existing resources. By utilizing the resources of an established Research Histology facility for tissue storage, processing, cutting of blocks, and staining of slides, it will be possible to achieve high standards for all histologic studies proposed in this grant. This centralization of histologic services under the supervision of a surgical pathologist with a dedicated interest in gastrointestinal pathology will allow careful attention to quality assurance.