JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

• 批准号: 8217112
• 负责人: ALEX L KOLODKIN
• 金额: $ 81.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8217112
• 关键词: 3-Dimensional; Address; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Antibodies; Archives; Area; Biochemical; Cells; Center Core Grants; Clinical; Communities; Complement; Core Facility; Custom; Data Set; Development; Dyes; Equipment; Event; Filament; Funding; Gene Expression Regulation; Gene Targeting; Generations; Goals; Grant; Hybrids; Image; Individual; Injury; Institution; Instruction; Ions; Laboratories; Lasers; Mental disorders; Methodology; Microscope; Monitor; Mono-S; Monoclonal Antibodies; Mus; National Institute of Neurological Disorders and Stroke; Natural regeneration; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurology; Neurons; Neurosciences; Neurosciences Research; Noise; Oryctolagus cuniculus; Pain Origin; Pathology; Phosphorylation; Photons; Physiologic Monitoring; Physiologic pulse; Protein Dynamics; Proteins; Reagent; Recording of previous events; Research; Research Personnel; Resolution; Resources; Running; Scanning; Scientist; Sensory; Services; Signal Transduction; Source; Specificity; Structure; Synapses; Tertiary Protein Structure; Time; Training; Transgenic Mice; Universities; base; cellular engineering; clinically relevant; embryonic stem cell; fluorophore; glial cell development; image processing; improved; instrumentation; medical schools; member; mouse model; nervous system disorder; neurodevelopment; operation; painful neuropathy; particle; programs; protein function; protein protein interaction; ranpirnase; reconstruction; sperm cell; two-photon; voltage

In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDSfunded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology,a nd one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.

在我们的机构中心核心补助金的竞争性更新中，我们支持神经科学研究， 建议保持和扩大约翰霍普金斯现有的三个核心设施的运作 大学医学院（JHU SOM）在本项目的上一个资助期内成立 中心资助：多光子成像核心、单克隆抗体核心和胚胎干细胞 工程核心这些设施目前提供必要的资源，并提供必要的服务， 这对于单个实验室来说是不切实际的。这些核心设施的使用将继续， 极大地受益于NINDS资助的11个主要中心研究人员的研究计划，以及其他 NINDS资助的调查人员在JHU SOM，通过提供独特的设备，新的培训， 方法和新试剂的开发。实验机会和技术服务 由这三个核心提供的补充，但不重复，其他核心设施提供给NINDS资助 JHU SOM的调查员11名主要中心研究者中有7名是 神经科学系，四名是神经内科的成员，一名是神经内科的成员。 病理学系。主要中心研究者的研究项目解决了未解决的 神经和神经胶质发育，突触结构和功能，感觉转导， 和基因表达的活性依赖性调节。主要中心研究者的具体目标 NINDS资助的研究项目旨在解决关键的临床问题，包括 神经系统疾病，促进损伤或变性后的神经元再生， 神经性疼痛的潜在基础，以及神经退行性疾病（阿尔茨海默氏痴呆症）的起源 和肌萎缩性侧索硬化症）。主要中心研究者组成了一个高度互动的小组 有着紧密合作研究的历史该中心的目标是扩大现有的 通过提供这些研究人员和JHU SOM的其他NINDS资助的研究人员， 拥有本机构其他地方无法提供的核心设施。