JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

• 批准号: 8441556
• 负责人: ALEX L KOLODKIN
• 金额: $ 14.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8441556
• 关键词: 3-Dimensional; Address; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Antibodies; Archives; Area; Biochemical; Cells; Center Core Grants; Clinical; Communities; Complement; Core Facility; Custom; Data Set; Development; Dyes; Equipment; Event; Filament; Funding; Gene Expression Regulation; Gene Targeting; Generations; Goals; Grant; Hybrids; Image; Individual; Injury; Institution; Instruction; Ions; Laboratories; Lasers; Mental disorders; Methodology; Microscope; Monitor; Mono-S; Monoclonal Antibodies; Mus; National Institute of Neurological Disorders and Stroke; Natural regeneration; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurology; Neurons; Neurosciences; Neurosciences Research; Noise; Oryctolagus cuniculus; Pain Origin; Pathology; Phosphorylation; Photons; Physiologic Monitoring; Physiologic pulse; Protein Dynamics; Proteins; Reagent; Recording of previous events; Research; Research Personnel; Resolution; Resources; Running; Scanning; Scientist; Sensory; Services; Signal Transduction; Source; Specificity; Structure; Synapses; Tertiary Protein Structure; Time; Training; Transgenic Mice; Universities; base; cellular engineering; clinically relevant; embryonic stem cell; fluorophore; glial cell development; image processing; improved; instrumentation; medical schools; member; mouse model; nervous system disorder; neurodevelopment; operation; painful neuropathy; particle; programs; protein function; protein protein interaction; ranpirnase; reconstruction; sperm cell; two-photon; voltage

PROJECT SUMMARY (See instructions): In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDSfunded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology,a nd one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.

项目摘要（参见说明）： 在我们的机构中​​心核心拨款的竞争性续签中，我们建议维持和扩大约翰·霍普金斯大学医学院 (JHU SOM) 的三个现有核心设施的运营，这些设施是在本中心拨款的上一个资助期间建立的：多光子成像核心、单克隆抗体核心和胚胎干细胞工程核心。这些设施目前提供必要的资源并执行所需的服务 个别实验室自行提供是不切实际的。通过提供独特的设备、新方法的培训和新试剂的开发，这些核心设施的使用将继续极大地有利于 NINDS 资助的 11 名主要中心研究人员以及 JHU SOM 其他 NINDS 资助的研究人员的研究项目。这三个核心提供的实验机会和技术服务补充但不重复 NINDSfunded 可用的其他核心设施 JHU SOM 的研究人员。十一名初级中心研究者中有七名是神经科学系的成员，四名是神经内科的成员，一名是病理科的成员。初级中心研究人员的研究项目致力于解决神经和神经胶质发育、突触结构和功能、感觉转导以及基因表达的活动依赖性调节等领域尚未解决的问题。初级中心研究者 NINDS 资助的研究项目的具体目标是解决关键的临床问题，包括发育起源 神经系统疾病、损伤或变性后神经元再生的促进、神经性疼痛的根本基础以及神经退行性疾病（阿尔茨海默氏痴呆和肌萎缩侧索硬化症）的起源。主要中心研究人员组成了一个高度互动的团队，有着无缝协作研究工作的历史。该中心的目标是通过为这些研究人员和 JHU SOM 的其他 NINDS 资助的研究人员提供增强现有的研究项目， 拥有该机构其他地方所没有的核心设施。