JHU Center for Neuroscience Research

约翰霍普金斯大学神经科学研究中心

• 批准号: 7455112
• 负责人: ALEX L KOLODKIN
• 金额: $ 73.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7455112
• 关键词: JHU; Center; Neuroscience; Research

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research we propose to establish three Core facilities. These facilities will provide necessary resources and will perform required services that are impractical for individual laboratories to provide on their own. They consist of a Multiphoton Imaging/Electrophysiology Core, an Embryonic Stem Cell Engineering Core, and a Monoclonal Antibody Core. The experimental opportunities and technical services to be offered by these Cores complement and do not duplicate existing Core facilities available to NINDS-funded investigators at the Johns Hopkins University School of Medicine (JHU SOM). The use of these Core facilities will greatly benefit the NINDS funded research programs of the ten primary investigators who constitute the primary investigators of this Center, and they will also be an important resource for all other NINDS-funded investigators at JHU SOM. Nine of the Center's ten primary investigators are members of the Department of Neuroscience, and the remaining investigator is a member of the Department of Neurology. The research programs of the Center's primary investigators address unresolved issues in the areas of neural development, regulation of synaptic structure and function, ion channel physiology and neurotransmitter transporter function, and activity dependent regulation of gene expression. The Specific Aims of these primary investigator's NINDS research programs address critical clinical issues, including the developmental basis of neurological disorders, the promotion of neuronal regeneration folowing injury or degeneration, and the origin of neurodegenerative disorders such as Alzheimer's Dementia and ALS. The Center's Primary Investigators define a highly interactive group with a strong history of seamless collaborative research efforts. It is the primary goal of this Center to provide these investigators, and all other NINDS-funded investigators at JHU SOM with core facilities that are not currently available in order to augment their existing research programs.

描述（由申请人提供）：在支持神经科学研究的机构中心核心拨款中，我们建议建立三个核心设施。这些设施将提供必要的资源，并提供个别实验室无法自行提供的所需服务。它们由多光子成像/电生理学核心、胚胎干细胞工程核心和单克隆抗体核心组成。这些核心提供的实验机会和技术服务是对约翰·霍普金斯大学医学院 (JHU SOM) NINDS 资助的研究人员可用的现有核心设施的补充，而不是重复。这些核心设施的使用将大大有利于构成该中心主要研究人员的 10 名主要研究人员的 NINDS 资助的研究项目，并且它们也将成为 JHU SOM 所有其他 NINDS 资助的研究人员的重要资源。该中心的十名主要研究人员中有九名是神经科学系的成员，其余的研究人员是神经病学系的成员。该中心主要研究人员的研究项目解决了神经发育、突触结构和功能调节、离子通道生理学和神经递质转运蛋白功能以及基因表达的活动依赖性调节等领域尚未解决的问题。这些主要研究者的 NINDS 研究计划的具体目标是解决关键的临床问题，包括神经系统疾病的发育基础、损伤或变性后神经元再生的促进，以及阿尔茨海默氏痴呆和 ALS 等神经退行性疾病的起源。该中心的主要研究人员定义了一个高度互动的团队，具有无缝协作研究工作的悠久历史。该中心的主要目标是为这些研究人员以及 JHU SOM 的所有其他 NINDS 资助的研究人员提供目前尚不可用的核心设施，以增强他们现有的研究项目。